IHEP OpenIR  > 多学科研究中心
Oxidative Stress and Acute Changes in Murine Brain Tissues After Nasal Instillation of Copper Particles with Different Sizes
刘洋(多); Gao YX(高愈希); Liu Y(刘颖); Li B(李柏); 陈春英Liu, Y; Gao, YX; Liu, Y; Li, B; Chen, CY; Wu, G
2014
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号14期号:6页码:4534-4540
摘要We aim to investigate the biological effects of copper particles on the murine brain and their underlying mechanism after nasal instillation of copper particles. We choose different sizes and different concentrations of copper nanoparticles for mice intranasal use. Within one week, the mice were sacrificed. Pathological lesions of glial cells were detected by immunohistochemical assay. Immunohistochemical assay reveals that glial fibrillary acidic protein (GFAP) increased significantly in all experimental groups, especially in nanocopper groups. The ultrastructure of nerve cells was observed through TEM, whose results show that there were chromatin congregation and mitochondria shrinkage in the olfactory cells, and that there was increase of endoplasmic reticulum and disassociation of endoplasmic reticulum ribosomes in hippocampus, particularly in the nanocopper-groups. Oxidative stress indexes were determined with colorimetric methods. There was no significant increase in the antioxidative enzymes (GPX, GST, SOD) in brain tissues; however, significant increase of malondiadehyde (MDA) contents was only found in the Cu nanoparticle-exposed mice at the high dose of 40 mg per kg body weight. Based on the investigation into the biological effects of copper nanoparticles (23.5 nm) after intranasal instillation to the mice, we have found that copper particles can indeed enter into the olfactory bulb and then the deeper brain. The inhalation of high dose copper nanoparticles can induce severer lesions of brain in the experimental mice. The underlying mechanism of copper nanoparticles causing severe brain damage bears little connection with oxidative stress.
关键词Copper Nanoparticle Brain Damage Biological Effect Oxidative Stress
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2014.8290
收录类别SCI
WOS记录号WOS:000332339500082
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225126
专题多学科研究中心
推荐引用方式
GB/T 7714
Liu Y,Gao YX,Liu Y,et al. Oxidative Stress and Acute Changes in Murine Brain Tissues After Nasal Instillation of Copper Particles with Different Sizes[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2014,14(6):4534-4540.
APA 刘洋.,高愈希.,刘颖.,李柏.,陈春英Liu, Y.,...&Wu, G.(2014).Oxidative Stress and Acute Changes in Murine Brain Tissues After Nasal Instillation of Copper Particles with Different Sizes.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,14(6),4534-4540.
MLA 刘洋,et al."Oxidative Stress and Acute Changes in Murine Brain Tissues After Nasal Instillation of Copper Particles with Different Sizes".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 14.6(2014):4534-4540.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11131.pdf(8208KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[刘洋(多)]的文章
[高愈希]的文章
[刘颖]的文章
百度学术
百度学术中相似的文章
[刘洋(多)]的文章
[高愈希]的文章
[刘颖]的文章
必应学术
必应学术中相似的文章
[刘洋(多)]的文章
[高愈希]的文章
[刘颖]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。