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Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis
Song Y(宋炎); Jin JJ(金俊江); Li J(李娟); Song, Y; Jin, JJ; Li, J; He, R; Zhang, MY; Chang, YA; Chen, K; Wang, Y; Sun, BY; Xing, GM; He R(何睿); Zhang MY(张铭倚); Chang YN(常亚男); Sun BY(孙宝云); Xing GM(邢更妹)
2014
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号14期号:6页码:4022-4028
摘要Macrophages can be recruited to tumor tissues and play a supportive role in the invasion microenvironment. Since nanoparticles can be easily endocytosed by this kind of cell, the advances in nanotechnology offer a new sight to target macrophages in tumor tissues for diminishing harmful phenotypes. In the xenograft mouse model, we found that metallofullerol Gd@C-82(OH)(22) can not only reduced the macrophage density in the tumor tissue, but also decreased the expression of matrix metalloproteinase-9 produced by this kind of cell. To verify the phenomenon, a macrophage cell line, RAW264.7 was employed in the experiment, in vivo. Gd@C-82(OH)(22) nanoparticles can be engulfed by macrophages and the quantity was measured by inductively coupled plasma mass spectrometry. Fluorescent staining result showed that the particle induced the cells to adopt an elongated spindle morphology. The morphology alteration implied that the cells undergo mesenchymal migration, which is assisted by matrix metalloproteinase-9 to break down the extracellular matrix. But the reverse transcription PCR and western blots results indicated that the expression of matrix metalloproteinase-9 was reduced after the treatment of Gd@C-82(OH)(22). Thus, transwell migration assay indicated that macrophages were constrained to migrate through the collagen matrix.
关键词Gd@C-82(OH)(22) Nanoparticles Tumor Macrophages Cell Morphology
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2014.8277
收录类别SCI
WOS记录号WOS:000332339500003
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225124
专题多学科研究中心
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Song Y,Jin JJ,Li J,et al. Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2014,14(6):4022-4028.
APA 宋炎.,金俊江.,李娟.,Song, Y.,Jin, JJ.,...&邢更妹.(2014).Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,14(6),4022-4028.
MLA 宋炎,et al."Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 14.6(2014):4022-4028.
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