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Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy
Zheng XP(郑晓鹏); Zhou LJ(周亮君); Yin WY(尹文艳); Zheng, XP; Zhou, LJ; Bu, Y; Yin, WY; Hu, ZB; Li, M; Gu, ZJ; Zhao, YL; Li M(李萌); Gu ZJ(谷战军); Zhao YL(赵宇亮)
2014
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
卷号2期号:38页码:6508-6516
摘要The combined use nanotechnology and medical technologies holds great promise for the development and improvement of various theranostic media. Here, based on a facile hydrothermal method, polyethyleneimine (PEI) functionalized YbPO4: Er up-conversion porous nanospheres (UCPSs) were fabricated, which combined the capabilities of up-conversion luminescence (UCL)/X-ray computed tomography (CT) bimodal imaging and drug delivery. The resulting hydrophilic PEI functionalized YbPO4: Er UCPSs (PEI-UCPSs) showed uniform morphology and high crystallinity. Moreover, PEI-UCPSs possessed high drug loading capacity because of their large specific surface area, which was confirmed by the Brunauer-Emmett-Teller (BET) experiment. Cellular experiments indicated that the PEI-UCPSs had low cytotoxicity and confirmed the performance of the pH-mediated cancer targeting of PEI-UCPSs@DOX. Importantly, because of the ideal UCL property and high CT contrast both in vitro and in vivo, YbPO4: Er PEI-UCPSs could be used as an optical probe and a contrast agent for optical and CT imaging, forming a promising platform for simultaneous bioimaging and drug delivery.
学科领域Materials Science
DOI10.1039/c4tb00880d
收录类别SCI
WOS记录号WOS:000342079900008
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225113
专题多学科研究中心
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Zheng XP,Zhou LJ,Yin WY,et al. Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(38):6508-6516.
APA 郑晓鹏.,周亮君.,尹文艳.,Zheng, XP.,Zhou, LJ.,...&赵宇亮.(2014).Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy.JOURNAL OF MATERIALS CHEMISTRY B,2(38),6508-6516.
MLA 郑晓鹏,et al."Er3+-doped YbPO4 up-conversion porous nanospheres for UCL/CT bimodal imaging in vivo and chemotherapy".JOURNAL OF MATERIALS CHEMISTRY B 2.38(2014):6508-6516.
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