Engineered design of theranostic upconversion nanoparticles for tri-modal upconversion luminescence/magnetic resonance/X-ray computed tomography imaging and targeted delivery of combined anticancer drugs
Gan T(甘田); Yin WY(尹文艳); Jin JJ(金俊江); Tian, G; Yin, WY; Jin, JJ; Zhang, X; Xing, GM; Li, SJ; Gu, ZJ; Zhao, YL;; Zhang X(张潇); Xing GM(邢更妹); Gu ZJ(谷战军); Zhao YL(赵宇亮)
刊名JOURNAL OF MATERIALS CHEMISTRY B
2014
卷号2期号:10页码:1379-1389
学科分类Materials Science
DOI10.1039/c3tb21394c
英文摘要Upconversion nanoparticles (UCNPs) are ideal building blocks for fabricating multifunctional theranostic agents for simultaneous diagnosis and therapy. We develop multifunctional nanoparticles based on NaGdF4:Yb/Er@NaGdF4 core-shell UCNPs, which are not only endowed with upconversion luminescence (UCL), magnetic resonance (MR) and X-ray computed tomography (CT) imaging ability, but also could be applied as nanocarriers for targeted drug delivery. We systematically investigate their upconversion luminescent, magnetic and X-ray attenuation properties. Importantly, for the first time, we report the controlled loading and delivery of a mixture of chemotherapeutic anticancer drugs, camptothecin (CPT) and doxorubicin (DOX), through UCNPs-based nanocarriers considering that the combined use of two or more drugs usually exhibits much better therapeutic efficacy than that of a single drug. By conjugating nanoparticles with folic acid (FA), which targets folate receptors over expressed on various types of cancer cells, we further demonstrate targeted tri-modal UCL/MR/CT cell imaging and drug delivery with UCNPs. Our results suggest the as-prepared nanocomposites are highly versatile and could potentially be used for simultaneous imaging and therapeutic applications.
收录类别SCI
WOS记录号WOS:000332199900011
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225112
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Gan T,Yin WY,Jin JJ,et al. Engineered design of theranostic upconversion nanoparticles for tri-modal upconversion luminescence/magnetic resonance/X-ray computed tomography imaging and targeted delivery of combined anticancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(10):1379-1389.
APA 甘田.,尹文艳.,金俊江.,Tian, G.,Yin, WY.,...&赵宇亮.(2014).Engineered design of theranostic upconversion nanoparticles for tri-modal upconversion luminescence/magnetic resonance/X-ray computed tomography imaging and targeted delivery of combined anticancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,2(10),1379-1389.
MLA 甘田,et al."Engineered design of theranostic upconversion nanoparticles for tri-modal upconversion luminescence/magnetic resonance/X-ray computed tomography imaging and targeted delivery of combined anticancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 2.10(2014):1379-1389.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11117.pdf(1316KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[甘田]的文章
[尹文艳]的文章
[金俊江]的文章
百度学术
百度学术中相似的文章
[甘田]的文章
[尹文艳]的文章
[金俊江]的文章
必应学术
必应学术中相似的文章
[甘田]的文章
[尹文艳]的文章
[金俊江]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 11117.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。