Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion
Fang, GL; Zhang, DC; Yin, HL; Zheng, L; Bi, XL; Yuan, L;秘晓林
刊名JOURNAL OF CELL SCIENCE
2014
卷号127期号:8页码:1631-1639
关键词Centrosome cohesion Centlein Cep68 C-Nap1 Rootletin
学科分类Cell Biology
DOI10.1242/jcs.139451
英文摘要Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still largely unknown. In this study, we show that the centriolar protein centlein (also known as CNTLN) localizes to the proximal ends of the centrioles and directly interacts with both C-Nap1 (also known as Cep250) and Cep68. Moreover, centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase and functions as a molecular link between C-Nap1 and Cep68. Depletion of centlein impairs recruitment of Cep68 to the centrosomes and, in turn, results in centrosome splitting. Both centlein and Cep68 are novel Nek2A substrates. Collectively, our data demonstrate that centrosome cohesion is maintained by the newly identified complex of C-Nap1-centlein-Cep68.
收录类别SCI
WOS记录号WOS:000334595500002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225070
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
推荐引用方式
GB/T 7714
Fang, GL,Zhang, DC,Yin, HL,et al. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion[J]. JOURNAL OF CELL SCIENCE,2014,127(8):1631-1639.
APA Fang, GL,Zhang, DC,Yin, HL,Zheng, L,Bi, XL,&Yuan, L;秘晓林.(2014).Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.JOURNAL OF CELL SCIENCE,127(8),1631-1639.
MLA Fang, GL,et al."Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion".JOURNAL OF CELL SCIENCE 127.8(2014):1631-1639.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11019.pdf(4862KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, GL]的文章
[Zhang, DC]的文章
[Yin, HL]的文章
百度学术
百度学术中相似的文章
[Fang, GL]的文章
[Zhang, DC]的文章
[Yin, HL]的文章
必应学术
必应学术中相似的文章
[Fang, GL]的文章
[Zhang, DC]的文章
[Yin, HL]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 11019.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。