Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study
Liu, F; Cao, X; Liu SQ(刘双全); Liu, SQ; Zhang, B; He, W; Song, JP; Dai, ZQ; Zhang, B; Luo, JW; Li, YH; Shan, BC; Bai, J;单保慈
刊名JOURNAL OF BIOPHOTONICS
2014
卷号7期号:11-12页码:889-896
关键词dual modality fluorescence [F-18]FDG-PET molecular imaging tomography
学科分类Biochemistry & Molecular Biology; Biophysics
DOI10.1002/jbio.201300069
英文摘要Dual modality molecular imaging can capture concurrent molecular events and evaluate therapeutic efficacy from uniquely different perspectives based on different molecular targets. In this work, dual modality tomographic imaging, F-18-fluorodeoxyglucose based positron emission tomography and subsurface fluorescence molecular tomography ([F-18]FDG-PET/subsurface FMT), is proposed to monitor tumor response to cisplatin on a mouse xenograft model in vivo. One mouse was administered with cisplatin (1.0 mg/kg) by intraperitoneal injection once every day for 14 days, and another mouse was administered with saline to serve as the control. Dual modality [F-18]FDG-PET/subsurface FMT imaging was conducted on days 0, 2, 5, 9, 15, and 22. In vivo imaging and quantitative analysis demonstrated the feasibility of [F-18]FDG-PET/subsurface FMT imaging in tracking the changes of [F-18]FDG tumor uptake and amount of red fluorescent protein (RFP) synthesized by tumor cells in the same mouse simultaneously. Dual modality [F-18]FDG-PET/subsurface FMT imaging may thus provide a powerful tool for better understanding disease progress and treatment evaluation from different perspectives. ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
收录类别SCI
WOS记录号WOS:000344651800004
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225068
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
中国科学院高能物理研究所_核技术应用研究中心
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Liu, F,Cao, X,Liu SQ,et al. Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study[J]. JOURNAL OF BIOPHOTONICS,2014,7(11-12):889-896.
APA Liu, F.,Cao, X.,刘双全.,Liu, SQ.,Zhang, B.,...&Bai, J;单保慈.(2014).Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study.JOURNAL OF BIOPHOTONICS,7(11-12),889-896.
MLA Liu, F,et al."Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study".JOURNAL OF BIOPHOTONICS 7.11-12(2014):889-896.
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