Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity
Yuan Q(袁卿); Han J(韩晶); Cong WS(丛文姝); Yuan, Q; Han, J; Cong, WS; Ge, Y; Ma, DD; Dai, ZX; Li, YP; Bi, XL;; Ma DD(马丹丹); Mi XL(秘晓林)
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
2014
卷号9页码:4829-4846
关键词docetaxel docetaxel-loaded solid lipid nanoparticles breast cancer toxicity
学科分类Science & Technology - Other Topics; Pharmacology & Pharmacy
DOI10.2147/IJN.S70919
英文摘要Docetaxel is an adjuvant chemotherapy drug widely used to treat multiple solid tumors; however, its toxicity and side effects limit its clinical efficacy. Herein, docetaxel-loaded solid lipid nanoparticles (DSNs) were developed to reduce systemic toxicity of docetaxel while still keeping its anticancer activity. To evaluate its anticancer activity and toxicity, and to understand the molecular mechanisms of DSNs, different cellular, molecular, and whole genome transcription analysis approaches were utilized. The DSNs showed lower cytotoxicity compared with the commercial formulation of docetaxel (Taxotere(R)) and induced more apoptosis at 24 hours after treatment in vitro. DSNs can cause the treated cancer cells to arrest in the G2/M phase in a dose-dependent manner similar to Taxotere. They can also suppress tumor growth very effectively in a mice model with human xenograft breast cancer. Systemic analysis of gene expression profiles by microarray and subsequent verification experiments suggested that both DSNs and Taxotere regulate gene expression and gene function, including DNA replication, DNA damage response, cell proliferation, apoptosis, and cell cycle regulation. Some of these genes expressed differentially at the protein level although their messenger RNA expression level was similar under Taxotere and DSN treatment. Moreover, DSNs improved the main side effect of Taxotere by greatly lowering myelosuppression toxicity to bone marrow cells from mice. Taken together, these results expound the antitumor efficacy and the potential working mechanisms of DSNs in its anticancer activity and toxicity, which provide a theoretical foundation to develop and apply a more efficient docetaxel formulation to treat cancer patients.
收录类别SCI
WOS记录号WOS:000343168000001
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225048
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Yuan Q,Han J,Cong WS,et al. Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:4829-4846.
APA 袁卿.,韩晶.,丛文姝.,Yuan, Q.,Han, J.,...&秘晓林.(2014).Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,4829-4846.
MLA 袁卿,et al."Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):4829-4846.
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