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Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
Peng, L; He X(何潇); 张鹏(多); He, X; Zhang, P; Zhang, J; Li, YY; Zhang, JZ; Ma, YH; Ding, YY; Wu, ZQ; Chai, ZF; Zhang, ZY;; Li YY(李媛媛); Ma YH(马宇辉); Ding YY(丁雅韵); Chai ZF(柴之芳); Zhang ZY(张智勇); Zhang J(张静)
2014
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1661-6596
EISSN1422-0067
Volume15Issue:4Pages:6072-6085
AbstractCeria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3-5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive.
Keywordnano-ceria pulmonary toxicity agglomerates size distribution surface chemistry
Subject AreaChemistry
DOI10.3390/ijms15046072
Indexed BySCI
Language英语
WOS IDWOS:000336841200060
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/225047
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
Peng, L,He X,Zhang P,et al. Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(4):6072-6085.
APA Peng, L.,何潇.,张鹏.,He, X.,Zhang, P.,...&张静.(2014).Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(4),6072-6085.
MLA Peng, L,et al."Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.4(2014):6072-6085.
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