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DNA/protein interaction and cytotoxicity of palladium(II) complexes of thiocarboxamide ligands
Sindhuja, E; Ramesh, R; Dharmaraj, N; Liu, Y; 刘宇(多)
2014
发表期刊INORGANICA CHIMICA ACTA
卷号416页码:1-12
摘要Four planar palladium(II) complexes with general formula [Pd(Cl)(L)(PPh3)] (HL = N-substituted pyridine-2- thiocarboxamide) have been synthesized and characterized by analytical, spectral (IR, UV-Vis and H-1, C-13 and P-31 NMR) and single crystal X-ray methods. Crystal structure of all the complexes indicated a mono negative bidentate coordination of thiocarboxamide ligands to the palladium center via pyridine nitrogen and thiol sulfur and reveals a square planar geometry. The interaction of palladium(II) thiocarboxamide complexes with calf thymus DNA (CT-DNA) studied by absorption and emission spectroscopic methods revealed that complexes 5-8 could interact with CT-DNA through intercalation. Further, the interaction of the palladium complexes with bovine serum albumin (BSA) was investigated using UV-Vis, fluorescence and synchronous fluorescence methods. The tryptophan and tyrosine residues in BSA as model protein was quenched by the complexes in a static quenching process. The radical scavenging ability of all the complexes was accessed by in vitro antioxidant assays involving DPPH radical, hydroxyl radical, nitric oxide radical and ABTS radicals and was found to be excellent. Further, the anti-cancer activity of complexes 5-8 against HeLa, MCF-7 and NIH-3T3 cell line has been studied. Though the complexes 5, 6 and 8 showed more potent anticancer activity than cisplatin, complex 5 was found to be superior. (C) 2014 Elsevier B.V. All rights reserved.
关键词Palladium(II) complex DNA/protein interaction Antioxidant Anticancer activity
学科领域Chemistry
DOI10.1016/j.ica.2014.03.002
收录类别SCI
WOS记录号WOS:000336459900001
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225038
专题核技术应用研究中心
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Sindhuja, E,Ramesh, R,Dharmaraj, N,et al. DNA/protein interaction and cytotoxicity of palladium(II) complexes of thiocarboxamide ligands[J]. INORGANICA CHIMICA ACTA,2014,416:1-12.
APA Sindhuja, E,Ramesh, R,Dharmaraj, N,Liu, Y,&刘宇.(2014).DNA/protein interaction and cytotoxicity of palladium(II) complexes of thiocarboxamide ligands.INORGANICA CHIMICA ACTA,416,1-12.
MLA Sindhuja, E,et al."DNA/protein interaction and cytotoxicity of palladium(II) complexes of thiocarboxamide ligands".INORGANICA CHIMICA ACTA 416(2014):1-12.
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