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Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60
Chang XL(常雪灵); Ruan LF(阮龙飞); Yang ST(杨胜韬); Chang, XL; Ruan, LF; Yang, ST; Sun, BY; Guo, CB; Zhou, LJ; Dong, JQ; Yuan, H; Xing, GM; Zhao, YL; Yang, M; Sun BY(孙宝云); Guo CB(郭翠彬); Zhou LJ(周亮君); Dong JQ(董金泉); Yuan H(袁慧); Xing GM(邢更妹); Zhao YL(赵宇亮)
2014
发表期刊ENVIRONMENTAL SCIENCE-NANO
卷号1期号:1页码:64-70
摘要Concerns over the biosafety of carbon nanomaterials have been raised, due to their unique structure, properties and applications. However, a lack of easily accessible quantification methods for in vivo carbon nanomaterials largely limits the evaluation of their biosafety. Here, for the first time we adopted C-13 stable isotopic labeling for the quantification of a fullerene in vivo. C-13-enriched fullerene C-60 was synthesized by arc discharge and purified by high performance liquid chromatography. The C-13-enriched C-60 was dispersed in tween 80 aqueous solution for animal administration and was then monitored and quantified by isotope ratio mass spectrometry after intravenous injection (i.v.). Our results showed that C-60 quickly cleared from the blood circulation with a half-life of 14 min, and selective accumulation in the liver, spleen and lungs was observed, with slight decreases seen within 24 h. The pharmacokinetics of C-60 could be evaluated using the two-compartmental model, in which the fast clearance after i.v. from the blood circulation and slow clearance by the uptake in tissues were revealed. The present findings demonstrated the feasibility of using C-13 stable isotopically labeled carbon nanomaterials such as fullerene to trace and quantitatively monitor their bio-behavior in vivo, and suggested that C-13-enriched carbon nanomaterials might bring about a new platform to study the environmental fate of carbon nanomaterials.
学科领域Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics
DOI10.1039/c3en00046j
收录类别SCI
WOS记录号WOS:000347971700007
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225004
专题多学科研究中心
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Chang XL,Ruan LF,Yang ST,et al. Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60[J]. ENVIRONMENTAL SCIENCE-NANO,2014,1(1):64-70.
APA 常雪灵.,阮龙飞.,杨胜韬.,Chang, XL.,Ruan, LF.,...&赵宇亮.(2014).Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60.ENVIRONMENTAL SCIENCE-NANO,1(1),64-70.
MLA 常雪灵,et al."Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60".ENVIRONMENTAL SCIENCE-NANO 1.1(2014):64-70.
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