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Design of multifunctional alkali ion doped CaF2 upconversion nanoparticles for simultaneous bioimaging and therapy
Yin WY(尹文艳); Tian G(田甘); Ren WL(任文璐); Yin, WY; Tian, G; Ren, WL; Yan, L; Jin, S; Gu, ZJ; Zhou, LJ; Li, J; Zhao, YL; Yan L(晏亮); Jin S(金山); Gu ZJ(谷战军); Zhou LJ(周亮君); Li J(李娟); Zhao YL(赵宇亮)
2014
发表期刊DALTON TRANSACTIONS
卷号43期号:10页码:3861-3870
摘要Herein, alkali ion doped CaF2 upconversion nanoparticles (UCNPs) were first reported as a multifunctional theranostic platform for dual-modal imaging and chemotherapy. Interestingly, we found that the alkali ions doping approach could efficiently enhance the upconversion luminescence (UCL) intensity, whereas slightly affect the phase and morphology of the resulting products. In order to further improve the UCL efficacy for bioimaging, a pristine CaF2 shell was grown on the CaF2:Yb, Er core surface to enhance the UCL intensity. After being transferred into hydrophilic UCNPs, these water-soluble UCNPs could be served as contrast agents for in vitro/in vivo UCL imaging and X-ray computed tomography (CT) imaging. Furthermore, the as-prepared UCNPs could also be employed as nano-carriers for drug delivery. Doxorubicin (DOX) can be easily loaded onto the UCNPs and the DOX-loaded UCNPs exhibit a good cell killing ability. Therefore, the multifunctional core-shell CaF2 UCNPs with UCL/CT imaging and drug carrier properties may find extensive applications in simultaneous imaging diagnosis and therapy.
学科领域Chemistry
DOI10.1039/c3dt52815d
收录类别SCI
WOS记录号WOS:000331230900006
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224987
专题多学科研究中心
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GB/T 7714
Yin WY,Tian G,Ren WL,et al. Design of multifunctional alkali ion doped CaF2 upconversion nanoparticles for simultaneous bioimaging and therapy[J]. DALTON TRANSACTIONS,2014,43(10):3861-3870.
APA 尹文艳.,田甘.,任文璐.,Yin, WY.,Tian, G.,...&赵宇亮.(2014).Design of multifunctional alkali ion doped CaF2 upconversion nanoparticles for simultaneous bioimaging and therapy.DALTON TRANSACTIONS,43(10),3861-3870.
MLA 尹文艳,et al."Design of multifunctional alkali ion doped CaF2 upconversion nanoparticles for simultaneous bioimaging and therapy".DALTON TRANSACTIONS 43.10(2014):3861-3870.
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