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Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function
Yang WJ(杨文江); 刘宇(多);Yang, W; Zhang, X; Liu, Y
2014
发表期刊CURRENT MEDICINAL CHEMISTRY
卷号21期号:SI1页码:4-23
摘要The number of Asialoglycoprotein (ASGP) receptors on the hepatocytes of patients with liver disease is reduced and is thus considered a good indicator for the evaluation of liver function. ASGP receptor-targeted radiopharmaceuticals permit a non-invasive way to evaluate total and regional hepatic function and hepatic functional reserve visually and quantitatively. Over the past three decades, a variety of ASGP receptor-targeted probes have been developed with different molecular backbones (albumin, polymer, small-molecular-weight ligand), different glycol-residues (galactose, lactose, N-acetyl-galactosamine) and different chelating systems suitable for radiolabeling with SPECT isotopes (Tc-99m, In-111, Ga-67, (131)/I-125, Sm-153) and PET isotopes (Ga-68, F-18). In this review, we present an overview of ASGP receptor-targeted radiopharmaceuticals, discuss their chemistry, biodistribution, catabolism and challenge as well as application for measurement of liver function.
关键词ASGP receptors hepatic imaging liver function PET radiopharmaceutical SPECT
学科领域Biochemistry & Molecular Biology; Pharmacology & Pharmacy
收录类别SCI
WOS记录号WOS:000327778900003
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224986
专题核技术应用研究中心
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GB/T 7714
Yang WJ,Liu Y,Zhang, X,et al. Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function[J]. CURRENT MEDICINAL CHEMISTRY,2014,21(SI1):4-23.
APA 杨文江,刘宇,Zhang, X,&Liu, Y.(2014).Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function.CURRENT MEDICINAL CHEMISTRY,21(SI1),4-23.
MLA 杨文江,et al."Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function".CURRENT MEDICINAL CHEMISTRY 21.SI1(2014):4-23.
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