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Toxicity of inorganic nanomaterials in biomedical imaging
Li JX(李金霞); Chang XL(常雪灵); Li, JX; Chang, XL; Chen, XX; Gu, ZJ; Zhao, F; Chai, ZF; Zhao, YL; Gu ZJ(谷战军); Zhao F(赵峰); Chai ZF(柴之芳); Zhao YL(赵宇亮)
AbstractInorganic nanoparticles have shown promising potentials as novel biomedical imaging agents with high sensitivity, high spatial and temporal resolution. To translate the laboratory innovations into clinical applications, their potential toxicities are highly concerned and have to be evaluated comprehensively both in vitro and in vivo before their clinical applications. In this review, we first summarized the in vivo and in vitro toxicities of the representative inorganic nanoparticles used in biomedical imagings. Then we further discuss the origin of nanotoxicity of inorganic nanomaterials, including ROS generation and oxidative stress, chemical instability, chemical composition, the surface modification, dissolution of nanoparticles to release excess free ions of metals, metal redox state, and left-over chemicals from synthesis, etc. We intend to provide the readers a better understanding of the toxicology aspects of inorganic nanomaterials and knowledge for achieving optimized designs of safer inorganic nanomaterials for clinical applications. (C) 2014 Elsevier Inc. All rights reserved.
KeywordMedical imaging Inorganic materials Nanomedicine Nanotoxicity Iron nanoparticles QDs Gold nanoparticles Upconversion nanoparticles
Subject AreaBiotechnology & Applied Microbiology
Indexed BySCI
WOS IDWOS:000338818300006
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Document Type期刊论文
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GB/T 7714
Li JX,Chang XL,Li, JX,et al. Toxicity of inorganic nanomaterials in biomedical imaging[J]. BIOTECHNOLOGY ADVANCES,2014,32(SI4):727-743.
APA 李金霞.,常雪灵.,Li, JX.,Chang, XL.,Chen, XX.,...&赵宇亮.(2014).Toxicity of inorganic nanomaterials in biomedical imaging.BIOTECHNOLOGY ADVANCES,32(SI4),727-743.
MLA 李金霞,et al."Toxicity of inorganic nanomaterials in biomedical imaging".BIOTECHNOLOGY ADVANCES 32.SI4(2014):727-743.
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