Toxicity of inorganic nanomaterials in biomedical imaging

doi:10.1016/j.biotechadv.2013.12.009

IHEP OpenIR > 院士

	Toxicity of inorganic nanomaterials in biomedical imaging
	Li JX(李金霞); Chang XL(常雪灵); Li, JX; Chang, XL; Chen, XX; Gu, ZJ; Zhao, F; Chai, ZF; Zhao, YL; Gu ZJ(谷战军); Zhao F(赵峰); Chai ZF(柴之芳); Zhao YL(赵宇亮)
	2014
发表期刊	BIOTECHNOLOGY ADVANCES (IF:10.597[JCR-2016],11.866[5-Year])
ISSN	0734-9750
EISSN	1873-1899
卷号	32 期号:SI4 页码:727-743
摘要	Inorganic nanoparticles have shown promising potentials as novel biomedical imaging agents with high sensitivity, high spatial and temporal resolution. To translate the laboratory innovations into clinical applications, their potential toxicities are highly concerned and have to be evaluated comprehensively both in vitro and in vivo before their clinical applications. In this review, we first summarized the in vivo and in vitro toxicities of the representative inorganic nanoparticles used in biomedical imagings. Then we further discuss the origin of nanotoxicity of inorganic nanomaterials, including ROS generation and oxidative stress, chemical instability, chemical composition, the surface modification, dissolution of nanoparticles to release excess free ions of metals, metal redox state, and left-over chemicals from synthesis, etc. We intend to provide the readers a better understanding of the toxicology aspects of inorganic nanomaterials and knowledge for achieving optimized designs of safer inorganic nanomaterials for clinical applications. (C) 2014 Elsevier Inc. All rights reserved.
关键词	Medical imaging Inorganic materials Nanomedicine Nanotoxicity Iron nanoparticles QDs Gold nanoparticles Upconversion nanoparticles
学科领域	Biotechnology & Applied Microbiology
DOI	10.1016/j.biotechadv.2013.12.009
收录类别	SCI
语种	英语
WOS记录号	WOS:000338818300006
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/224866
专题	院士多学科研究中心
推荐引用方式 GB/T 7714	Li JX,Chang XL,Li, JX,et al. Toxicity of inorganic nanomaterials in biomedical imaging[J]. BIOTECHNOLOGY ADVANCES,2014,32(SI4):727-743.
APA	李金霞.,常雪灵.,Li, JX.,Chang, XL.,Chen, XX.,...&赵宇亮.(2014).Toxicity of inorganic nanomaterials in biomedical imaging.BIOTECHNOLOGY ADVANCES,32(SI4),727-743.
MLA	李金霞,et al."Toxicity of inorganic nanomaterials in biomedical imaging".BIOTECHNOLOGY ADVANCES 32.SI4(2014):727-743.