On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells
Yan L(晏亮); Chang YN(常亚男); Yin WY(尹文燕); Yan, L; Chang, YN; Yin, WY; Tian, G; Zhou, LJ; Liu, XD; Xing, GM; Zhao, LN; Gu, ZJ; Zhao, YL; Tian G(田甘); Zhou LJ(周亮君); Liu XD(刘晓东); Xing GM(邢更妹); Zhao LN(赵丽娜); Gu ZJ(谷战军); Zhao YL(赵宇亮)
刊名BIOMATERIALS SCIENCE
2014
卷号2期号:10页码:1412-1418
学科分类Materials Science
DOI10.1039/c4bm00143e
英文摘要Graphene oxide (GO) has been proven to be a highly efficient long-range quencher for various fluorescence processes, which intrinsically work through a photophysical mechanism similar to that of singlet oxygen generation (SOG). Under our hypothesis that GO may be capable of quenching the SOG process, here we design and synthesize a novel nanocomplex consisting of GO, a photosensitizer and an aptamer. We demonstrate that GO is an ideal SOG controller, which can reversibly quench and recover SOG depending on the interaction intensity between GO and a photosensitizer. Additionally, it can simultaneously act as a carrier for the efficient loading and delivery of the photosensitizers to cancer cells. Thus, during the delivery process, SOG of the nanocomplex can be completely inhibited by the quenching capacity of the GO even though there is light present; however, when the nanocomplex enters into cancer cells where target molecules are present, SOG is triggered by a target binding event and singlet oxygen is reversibly released from the nanocomplex, ultimately inducing significant cell death in the presence of light. This proof-of-concept study provides a new chemical strategy for creating a highly selective photodynamic therapy with low toxicity, using hydrophilic GO-based systems.
收录类别SCI
WOS记录号WOS:000343034000011
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224864
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Yan L,Chang YN,Yin WY,et al. On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells[J]. BIOMATERIALS SCIENCE,2014,2(10):1412-1418.
APA 晏亮.,常亚男.,尹文燕.,Yan, L.,Chang, YN.,...&赵宇亮.(2014).On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells.BIOMATERIALS SCIENCE,2(10),1412-1418.
MLA 晏亮,et al."On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells".BIOMATERIALS SCIENCE 2.10(2014):1412-1418.
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