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Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
Gao FP(高福平); Yuan Q(袁卿); Gao J(高靓); Gao, FP; Yuan, Q; Gao, L; Cai, PJ; Zhu, HR; Liu, R; Wang, YL; Wei, YT; Huang, GD; Liang, J; Gao, XY;; Zhu HR(朱华瑞); Liu R(刘茹); Wang YL(王亚玲); Wei YT(魏岳腾); Gao XY(高学云)
2014
发表期刊BIOMATERIALS
卷号35期号:31页码:8854-8866
摘要Although chemotherapeutic drugs are widely applied for clinic tumor treatment, severe toxicity restricts their therapeutic efficacy. In this study, we reported a new form of selenium, selenium nanoparticles (Nano Se) which have significant lower toxicity and acceptable bioavailability. We investigated Nano Se as chemotherapy preventive agent to protect against toxicities of anticancer drug irinotecan and synergistically enhance the anti-tumor treatment effect in vitro and in vivo. The underlying mechanisms were also investigated. The combination of Nano Se and irinotecan showed increased cytotoxic effect with HCT-8 tumor cells likely by p53 mediated apoptosis. Nano Se inhibited growth of HCT-8 tumor cells partially through caspases mediated apoptosis. In vivo experiment showed Nano Se at a dose of 4 mg/kg/day significantly alleviated adverse effects induced by irinotecan (60 mg/kg) treatment. Nano Se alone treatment did not induce any toxic manifestations. The combination of Nano Se and irinotecan dramatically inhibited tumor growth and significantly induced apoptosis of tumor cells in HCT-8 cells xenografted tumor. Tumor inhibition rate was about 17.2%, 48.6% and 62.1% for Nano Se, irinotecan and the combination of Nano Se and irinotecan, respectively. The beneficial effects of Nano Se for tumor therapy were mainly ascribed to selectively regulating Nrf2-ARE (antioxidant responsive elements) pathway in tumor tissues and normal tissues. Our results suggest Nano Se is a promising selenium species with potential application in cancer treatment. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Selenium nanoparticle Toxicity Antitumor drug Apoptosis Nrf2-ARE pathway
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2014.07.004
收录类别SCI
WOS记录号WOS:000340984600011
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224862
专题多学科研究中心
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GB/T 7714
Gao FP,Yuan Q,Gao J,et al. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles[J]. BIOMATERIALS,2014,35(31):8854-8866.
APA 高福平.,袁卿.,高靓.,Gao, FP.,Yuan, Q.,...&高学云.(2014).Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles.BIOMATERIALS,35(31),8854-8866.
MLA 高福平,et al."Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles".BIOMATERIALS 35.31(2014):8854-8866.
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