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Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging
Zhou LJ(周亮君); Zheng XP(郑晓鹏); Gu ZJ(谷战军); Zhou, LJ; Zheng, XP; Gu, ZJ; Yin, WY; Zhang, X; Ruan, LF; Yang, YB; Hu, ZB; Zhao, YL; Yin WY(尹文艳); Zhang X(张潇); Ruan LF(阮龙飞); Yang YB(杨艳波); Zhao YL(赵宇亮)
2014
Source PublicationBIOMATERIALS
ISSN0142-9612
EISSN1878-5905
Volume35Issue:26Pages:7666-7678
AbstractWe developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r(1)) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordMesoporous Core-shell Up-conversion nanoparticles Targeted drug delivery Multimodality biomedical imaging
Subject AreaEngineering; Materials Science
DOI10.1016/j.biomaterials.2014.05.051
Indexed BySCI
Language英语
WOS IDWOS:000339035000039
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/224861
Collection多学科研究中心
Recommended Citation
GB/T 7714
Zhou LJ,Zheng XP,Gu ZJ,et al. Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging[J]. BIOMATERIALS,2014,35(26):7666-7678.
APA 周亮君.,郑晓鹏.,谷战军.,Zhou, LJ.,Zheng, XP.,...&赵宇亮.(2014).Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging.BIOMATERIALS,35(26),7666-7678.
MLA 周亮君,et al."Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging".BIOMATERIALS 35.26(2014):7666-7678.
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