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The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration
Zhou, HJ; Zhang, B; Zheng JJ(郑佳佳); Zheng, JJ; Yu, MF; Zhou, T; Zhao, K; Jia, YX; Gao, XF; Chen, CY; Wei, TT; Gao XF(高兴发); Chen CY(陈春英)
2014
发表期刊BIOMATERIALS
卷号35期号:5页码:1597-1607
摘要Graphene and its derivatives have become important nanomaterials worldwide and have potential medical applications including in vivo diagnosis, drug delivery, and photothermal therapy of cancer. However, little is known about their effect on the metastasis of cancer cells, which is the cause of over 90% of patient deaths. In the present investigation, we provide direct evidence that low concentrations of pristine graphene and graphene oxide show no apparent influence on the viability of MDA-MB-231 human breast cancer cells, PC3 human prostate cancer cells, as well as Bl6F10 mouse melanoma cells. However, both pristine graphene and graphene oxide can effectively inhibit the migration and invasion of these cancer cells. Further studies indicate that exposure of cells to graphene led to the direct inhibition of the electron transfer chain complexes I, II, III and IV, most likely by disrupting electron transfer between iron-sulfur centers, which is due to its stronger ability to accept electrons compared to ironsulfur clusters through theoretical calculations. The decreased electron transfer chain activity caused a reduction in the production of ATP and subsequent impairment of F-actin cytoskeleton assembly, which is crucial for the migration and invasion of metastatic cancer cells. The inhibition of cancer cell metastasis by graphene and graphene oxide might provide new insights into specific cancer treatment. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Graphene Cancer cell Metastasis Mitochondria Electron transfer chain Iron-sulfur center
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2013.11.020
收录类别SCI
WOS记录号WOS:000330156100024
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被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224859
专题多学科研究中心
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Zhou, HJ,Zhang, B,Zheng JJ,et al. The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration[J]. BIOMATERIALS,2014,35(5):1597-1607.
APA Zhou, HJ.,Zhang, B.,郑佳佳.,Zheng, JJ.,Yu, MF.,...&陈春英.(2014).The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration.BIOMATERIALS,35(5),1597-1607.
MLA Zhou, HJ,et al."The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration".BIOMATERIALS 35.5(2014):1597-1607.
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