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High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S-cerevisiae RNA endonuclease Swt1
彭淑霞;Peng, SX; Zhou, K; Wang, WJ; Gao, ZQ; Dong, YH; Liu, QS
2014
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号453期号:4页码:826-832
摘要Swt1 is an RNA endonuclease that plays an important role in quality control of nuclear messenger ribonucleoprotein particles (mRNPs) in eukaryotes; however, its structural details remain to be elucidated. Here, we report the crystal structure of the C-terminal (CT) domain of Swt1 from Saccharomyces cerevisiae, which shares common characteristics of higher eukaryotes and prokaryotes nucleotide binding (HEPN) domain superfamily. To study in detail the full-length protein structure, we analyzed the low-resolution architecture of Swt1 in solution using small angle X-ray scattering (SAXS) method. Both the CT domain and middle domain exhibited a good fit upon superimposing onto the molecular envelope of Swt1. Our study provides the necessary structural information for detailed analysis of the functional role of Swt1, and its importance in the process of nuclear mRNP surveillance. (C) 2014 Elsevier Inc. All rights reserved.
关键词HEPN domain Crystal structure RNA endonuclease SAXS Swt1
学科领域Biochemistry & Molecular Biology; Biophysics
DOI10.1016/j.bbrc.2014.10.040
收录类别SCI
WOS记录号WOS:000346329000025
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224857
专题多学科研究中心
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GB/T 7714
彭淑霞;Peng, SX,Zhou, K,Wang, WJ,et al. High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S-cerevisiae RNA endonuclease Swt1[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,453(4):826-832.
APA 彭淑霞;Peng, SX,Zhou, K,Wang, WJ,Gao, ZQ,Dong, YH,&Liu, QS.(2014).High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S-cerevisiae RNA endonuclease Swt1.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,453(4),826-832.
MLA 彭淑霞;Peng, SX,et al."High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S-cerevisiae RNA endonuclease Swt1".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453.4(2014):826-832.
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