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Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro
Gao J(高靓); Liu R(刘茹); Gao FP(高福平); Gao, H; Liu, R; Gao, FP; Wang, YL; Jiang, XL; Gao, XY;; Wang YL(王亚玲); Jiang XL(蒋兴禄); Gao XY(高学云)
2014
发表期刊ACS NANO
卷号8期号:7页码:7260-7271
摘要We have performed fundamental assays of gold nanocages (AuNCs) as intrinsic inorganic photosensitizers mediating generation of reactive oxygen species (ROS) by plasmon-enabled photochemistry under near-infrared (NIR) one/two-photon irradiation. We disclosed that NIR light excited hot electrons transform into either ROS or hyperthermia. Electron spin resonance spectroscopy was applied to demonstrate the production of three main radical species, namely, singlet oxygen (O-1(2)), superoxide radical anion (O-2(-center dot)), and hydroxyl radical ((OH)-O-center dot). The existence of hot electrons from irradiated AuNCs was confirmed by a well-designed photoelectrochemical experiment based on a three-electrode system. It could be speculated that surface plasmons excited in AuNCs first decay into hot electrons, and then the generated hot electrons sensitize oxygen to form ROS through energy and electron transfer modes. We also compared AuNCs' ROS generation efficiency in different surface chemical environments under one/two-photon irradiation and verified that, compared with one-photon irradiation, two-photon irradiation could bring about much more ROS. furthermore, in vitro, under two-photon irradiation, ROS can trigger mitochondrial depolarization and caspase protein up-regulation to initiate tumor cell apoptosis. Meanwhile, hyperthermia mainly induces tumor cell necrosis. Our findings suggest that plasmon-mediated ROS and hyperthermia can be facilely regulated for optimized anticancer phototherapy.
关键词gold nanocages reactive oxygen species photodynamic therapy plasmon-enabled photochemistry hot electrons two-photon
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/nn502325j
收录类别SCI
WOS记录号WOS:000339463100083
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被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224787
专题多学科研究中心
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Gao J,Liu R,Gao FP,et al. Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro[J]. ACS NANO,2014,8(7):7260-7271.
APA 高靓.,刘茹.,高福平.,Gao, H.,Liu, R.,...&高学云.(2014).Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro.ACS NANO,8(7),7260-7271.
MLA 高靓,et al."Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro".ACS NANO 8.7(2014):7260-7271.
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