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High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy
Yin WY(尹文艳); Yan L(晏亮); Yu J(余杰); Yin, WY; Yan, L; Yu, J; Tian, G; Zhou, LJ; Zheng, XP; Zhang, X; Yong, Y; Li, J; Gu, ZJ; Zhao, YL; Tian G(田甘); Zhou LJ(周亮君); Zheng XP(郑晓鹏); Zhang X(张潇); Yong Y(雍媛); Li J(李娟); Gu ZJ(谷战军); Zhao YL(赵宇亮)
2014
Source PublicationACS NANO
ISSN1936-0851
EISSN1936-086X
Volume8Issue:7Pages:6922-6933
AbstractWe report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating MoS2 nanosheets with chitosan, these functionalized MoS2 nanosheets have been developed as a chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy. Loaded doxorubicin could be controllably released upon the photothermal effect induced by 808 nm NIR laser irradiation. In vitro and in vivo tumor ablation studies demonstrate a better synergistic therapeutic effect of the combined treatment, compared with either chemotherapy or photothermal therapy alone. Finally, MoS2 nanosheets can also be used as a promising contrast agent in X-ray computed tomography imaging due to the obvious X-ray absorption ability of Mo. As a result, the high-throughput oleum treatment exfoliation process could be extended for fabricating other 2D nanomaterials, and the NIR-triggered drug release strategy was encouraging for simultaneous imaging-guided cancer theranostic application.
Keywordsingle-layer MoS2 nanosheets high-throughput oleum treatment exfoliation strategy NIR-triggered drug delivery
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/nn501647j
Indexed BySCI
Language英语
WOS IDWOS:000339463100047
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/224786
Collection多学科研究中心
Recommended Citation
GB/T 7714
Yin WY,Yan L,Yu J,et al. High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy[J]. ACS NANO,2014,8(7):6922-6933.
APA 尹文艳.,晏亮.,余杰.,Yin, WY.,Yan, L.,...&赵宇亮.(2014).High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy.ACS NANO,8(7),6922-6933.
MLA 尹文艳,et al."High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy".ACS NANO 8.7(2014):6922-6933.
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