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High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy
Yin WY(尹文艳); Yan L(晏亮); Yu J(余杰); Yin, WY; Yan, L; Yu, J; Tian, G; Zhou, LJ; Zheng, XP; Zhang, X; Yong, Y; Li, J; Gu, ZJ; Zhao, YL; Tian G(田甘); Zhou LJ(周亮君); Zheng XP(郑晓鹏); Zhang X(张潇); Yong Y(雍媛); Li J(李娟); Gu ZJ(谷战军); Zhao YL(赵宇亮)
2014
发表期刊ACS NANO
卷号8期号:7页码:6922-6933
摘要We report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating MoS2 nanosheets with chitosan, these functionalized MoS2 nanosheets have been developed as a chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy. Loaded doxorubicin could be controllably released upon the photothermal effect induced by 808 nm NIR laser irradiation. In vitro and in vivo tumor ablation studies demonstrate a better synergistic therapeutic effect of the combined treatment, compared with either chemotherapy or photothermal therapy alone. Finally, MoS2 nanosheets can also be used as a promising contrast agent in X-ray computed tomography imaging due to the obvious X-ray absorption ability of Mo. As a result, the high-throughput oleum treatment exfoliation process could be extended for fabricating other 2D nanomaterials, and the NIR-triggered drug release strategy was encouraging for simultaneous imaging-guided cancer theranostic application.
关键词single-layer MoS2 nanosheets high-throughput oleum treatment exfoliation strategy NIR-triggered drug delivery
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/nn501647j
收录类别SCI
WOS记录号WOS:000339463100047
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被引频次:299[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224786
专题多学科研究中心
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Yin WY,Yan L,Yu J,et al. High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy[J]. ACS NANO,2014,8(7):6922-6933.
APA 尹文艳.,晏亮.,余杰.,Yin, WY.,Yan, L.,...&赵宇亮.(2014).High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy.ACS NANO,8(7),6922-6933.
MLA 尹文艳,et al."High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy".ACS NANO 8.7(2014):6922-6933.
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