Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles
Chang YN(常亚南); Chang, YN; 李娟; Guo, HL; Li, J; Song, Y; Zhang, MY; Jin, JJ; Xing, GM; Zhao, YL; Song Y(宋炎); Zhang MY(张铭倚); Xing GM(邢更妹); Zhao YL(赵宇亮)
刊名PLOS ONE
2013
卷号8期号:10页码:e76024
学科分类Science & Technology - Other Topics
DOI10.1371/journal.pone.0076024
英文摘要The nature of macrophage allows the possibility that this cell type could be used as drug delivery system to track therapeutic drug nanoparticles (NPs) in cancer. However, there is no existing research on the regulation between effective loading of NPs and targeted delivery of macrophages. Here, we investigated the important parameters of intracellular NP quantity and the vector migration rate. Macrophage loading capacity was obtained by comparing the uptake quantity of varisized NPs, and the delivery ability of loaded cells was determined by measuring vector migration rates. We observed a positive correlation between the size of NPs and directed macrophage migration. Our findings suggest that the molecular mechanism of migration vector rate regulation involved increased expression levels of colony-stimulating factor-1 (CSF-1) receptor and integrin induced by 100-nm and 500-nm particles. The ability of macrophages uptake to varisized NPs showed the opposite trend, with the increased vector rate of cell migration influenced by NPs. We are able to demonstrate the important balance between effective macrophage loading and targeted delivery. By adjusting the balance parameters, it will be possible to utilize NPs in macrophage-mediated disease diagnosis and therapy.
收录类别SCI
WOS记录号WOS:000325552200046
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224735
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Chang YN,Chang, YN,李娟; Guo, HL,et al. Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles[J]. PLOS ONE,2013,8(10):e76024.
APA 常亚南.,Chang, YN.,李娟; Guo, HL.,Li, J.,Song, Y.,...&赵宇亮.(2013).Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles.PLOS ONE,8(10),e76024.
MLA 常亚南,et al."Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles".PLOS ONE 8.10(2013):e76024.
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