Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles

doi:10.1371/journal.pone.0076024

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	Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles
	Chang YN(常亚南); Chang, YN; 李娟; Guo, HL; Li, J; Song, Y; Zhang, MY; Jin, JJ; Xing, GM; Zhao, YL; Song Y(宋炎); Zhang MY(张铭倚); Xing GM(邢更妹); Zhao YL(赵宇亮)
	2013
发表期刊	PLOS ONE
卷号	8 期号:10 页码:e76024
摘要	The nature of macrophage allows the possibility that this cell type could be used as drug delivery system to track therapeutic drug nanoparticles (NPs) in cancer. However, there is no existing research on the regulation between effective loading of NPs and targeted delivery of macrophages. Here, we investigated the important parameters of intracellular NP quantity and the vector migration rate. Macrophage loading capacity was obtained by comparing the uptake quantity of varisized NPs, and the delivery ability of loaded cells was determined by measuring vector migration rates. We observed a positive correlation between the size of NPs and directed macrophage migration. Our findings suggest that the molecular mechanism of migration vector rate regulation involved increased expression levels of colony-stimulating factor-1 (CSF-1) receptor and integrin induced by 100-nm and 500-nm particles. The ability of macrophages uptake to varisized NPs showed the opposite trend, with the increased vector rate of cell migration influenced by NPs. We are able to demonstrate the important balance between effective macrophage loading and targeted delivery. By adjusting the balance parameters, it will be possible to utilize NPs in macrophage-mediated disease diagnosis and therapy.
学科领域	Science & Technology - Other Topics
DOI	10.1371/journal.pone.0076024
收录类别	SCI
WOS记录号	WOS:000325552200046
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/224735
专题	多学科研究中心
推荐引用方式 GB/T 7714	Chang YN,Chang, YN,李娟； Guo, HL,et al. Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles[J]. PLOS ONE,2013,8(10):e76024.
APA	常亚南.,Chang, YN.,李娟； Guo, HL.,Li, J.,Song, Y.,...&赵宇亮.(2013).Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles.PLOS ONE,8(10),e76024.
MLA	常亚南,et al."Adjusting the Balance between Effective Loading and Vector Migration of Macrophage Vehicles to Deliver Nanoparticles".PLOS ONE 8.10(2013):e76024.

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