Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naive Patients with Obsessive-Compulsive Disorder

doi:10.1371/journal.pone.0067478

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	Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naive Patients with Obsessive-Compulsive Disorder
	Cheng, YQ; Xu, J; Nie BB(聂彬彬); Nie, BB; Luo, CR; Yang, T; Li, HJ; Lu, J; Xu, L; Shan, BC; Xu, XF;单保慈
	2013
发表期刊	PLOS ONE
卷号	8 期号:6 页码:e67478
摘要	Background: Obsessive-compulsive disorder (OCD) is a mental illness characterized by the loss of control. Because the cingulate cortex is believed to be important in executive functions, such as inhibition, we used functional magnetic resonance imaging (fMRI) techniques to examine whether and how activity and functional connectivity (FC) of the cingulate cortex were altered in drug-naive OCD patients. Methods: Twenty-three medication-naive OCD patients and 23 well-matched healthy controls received fMRI scans in a resting state. Functional connectivities of the anterior cingulate (ACC) and the posterior cingulate (PCC) to the whole brain were analyzed using correlation analyses based on regions of interest (ROI) identified by the fractional amplitude of low-frequency fluctuation (fALFF). Independent Component Analysis (ICA) was used to identify the resting-state sub-networks. Results: fALFF analysis found that regional activity was increased in the ACC and decreased in the PCC in OCD patients when compared to controls. FC of the ACC and the PCC also showed different patterns. The ACC and the PCC were found to belong to different resting-state sub-networks in ICA analysis and showed abnormal FC, as well as contrasting correlations with the severity of OCD symptoms. Conclusions: Activity of the ACC and the PCC were increased and decreased, respectively, in the medication-naive OCD patients compared to controls. Different patterns in FC were also found between the ACC and the PCC with respect to these two groups. These findings implied that the cardinal feature of OCD, the loss of control, may be attributed to abnormal activities and FC of the ACC and the PCC.
学科领域	Science & Technology - Other Topics
DOI	10.1371/journal.pone.0067478
收录类别	SCI
WOS记录号	WOS:000321148400089
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/224733
专题	核技术应用研究中心
推荐引用方式 GB/T 7714	Cheng, YQ,Xu, J,Nie BB,et al. Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naive Patients with Obsessive-Compulsive Disorder[J]. PLOS ONE,2013,8(6):e67478.
APA	Cheng, YQ.,Xu, J.,聂彬彬.,Nie, BB.,Luo, CR.,...&Xu, XF；单保慈.(2013).Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naive Patients with Obsessive-Compulsive Disorder.PLOS ONE,8(6),e67478.
MLA	Cheng, YQ,et al."Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naive Patients with Obsessive-Compulsive Disorder".PLOS ONE 8.6(2013):e67478.

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