Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure
Wang, J; Xing XQ(邢雪青); Xing, XQ; Fang, XC; Zhou, C; Huang, F; Wu, ZH; Lou, JZ; Liang, W;吴忠华
刊名PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
2013
卷号371期号:2000SI页码:20120309
关键词drug-polymer compatibility PEGylated phospholipid micelles molecular dynamics simulation small-angle X-ray scattering fluorescence resonance energy transfer
学科分类Science & Technology - Other Topics
DOI10.1098/rsta.2012.0309
英文摘要Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG-PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin and vinorelbine. However, gemcitabine and topotecan are not suitable for PEG-PE micelles due to lack of positive charge or hydrophobicity. Using a series of experiments and molecular modelling, we figured out the assembly mechanism, structure and stability of drug-loaded micelles, and the location of drugs in micelles. Integrating the above information, we explain the effect of the predominant force between drugs and polymers on the assembly mechanism and drug release behaviour. Furthermore, we discuss the importance of pK(a) and log P to evaluate the compatibility of drugs with PEG-PE in self-assembly preparation method. In summary, this work provides a scientific understanding for the reasonable designing of PEG-PE micelle-based drug encapsulation and might enlighten the future study on drug-polymer compatibility for other polymeric micelles.
收录类别SCI
WOS记录号WOS:000330311400008
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224718
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Wang, J,Xing XQ,Xing, XQ,et al. Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES,2013,371(2000SI):20120309.
APA Wang, J.,邢雪青.,Xing, XQ.,Fang, XC.,Zhou, C.,...&Liang, W;吴忠华.(2013).Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure.PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES,371(2000SI),20120309.
MLA Wang, J,et al."Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure".PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 371.2000SI(2013):20120309.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
10421.pdf(1285KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, J]的文章
[邢雪青]的文章
[Xing, XQ]的文章
百度学术
百度学术中相似的文章
[Wang, J]的文章
[邢雪青]的文章
[Xing, XQ]的文章
必应学术
必应学术中相似的文章
[Wang, J]的文章
[邢雪青]的文章
[Xing, XQ]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10421.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。