| Noise effects in nonlinear biochemical signaling | |
| Bostani, N; Kessler, DA; Shnerb, NM; Rappel, WJ; Levine, H | |
| 2012 | |
| 发表期刊 | PHYSICAL REVIEW E
 |
| 卷号 | 85期号:1页码:11901 |
| 摘要 | It has been generally recognized that stochasticity can play an important role in the information processing accomplished by reaction networks in biological cells. Most treatments of that stochasticity employ Gaussian noise even though it is a priori obvious that this approximation can violate physical constraints, such as the positivity of chemical concentrations. Here, we show that even when such nonphysical fluctuations are rare, an exact solution of the Gaussian model shows that the model can yield unphysical results. This is done in the context of a simple incoherent-feedforward model which exhibits perfect adaptation in the deterministic limit. We show how one can use the natural separation of time scales in this model to yield an approximate model, that is analytically solvable, including its dynamical response to an environmental change. Alternatively, one can employ a cutoff procedure to regularize the Gaussian result. |
| 学科领域 | Physics |
| DOI | 10.1103/PhysRevE.85.011901 |
| 收录类别 | SCI |
| WOS记录号 | WOS:000299120300010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ihep.ac.cn/handle/311005/224473 |
| 专题 | 粒子天体物理中心 |
| 推荐引用方式 GB/T 7714 | Bostani, N,Kessler, DA,Shnerb, NM,et al. Noise effects in nonlinear biochemical signaling[J]. PHYSICAL REVIEW E,2012,85(1):11901. |
| APA | Bostani, N,Kessler, DA,Shnerb, NM,Rappel, WJ,&Levine, H.(2012).Noise effects in nonlinear biochemical signaling.PHYSICAL REVIEW E,85(1),11901. |
| MLA | Bostani, N,et al."Noise effects in nonlinear biochemical signaling".PHYSICAL REVIEW E 85.1(2012):11901. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 8505.pdf（502KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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