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Noise effects in nonlinear biochemical signaling
Bostani, N; Kessler, DA; Shnerb, NM; Rappel, WJ; Levine, H
2012
发表期刊PHYSICAL REVIEW E
卷号85期号:1页码:11901
摘要It has been generally recognized that stochasticity can play an important role in the information processing accomplished by reaction networks in biological cells. Most treatments of that stochasticity employ Gaussian noise even though it is a priori obvious that this approximation can violate physical constraints, such as the positivity of chemical concentrations. Here, we show that even when such nonphysical fluctuations are rare, an exact solution of the Gaussian model shows that the model can yield unphysical results. This is done in the context of a simple incoherent-feedforward model which exhibits perfect adaptation in the deterministic limit. We show how one can use the natural separation of time scales in this model to yield an approximate model, that is analytically solvable, including its dynamical response to an environmental change. Alternatively, one can employ a cutoff procedure to regularize the Gaussian result.
学科领域Physics
DOI10.1103/PhysRevE.85.011901
收录类别SCI
WOS记录号WOS:000299120300010
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224473
专题粒子天体物理中心
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Bostani, N,Kessler, DA,Shnerb, NM,et al. Noise effects in nonlinear biochemical signaling[J]. PHYSICAL REVIEW E,2012,85(1):11901.
APA Bostani, N,Kessler, DA,Shnerb, NM,Rappel, WJ,&Levine, H.(2012).Noise effects in nonlinear biochemical signaling.PHYSICAL REVIEW E,85(1),11901.
MLA Bostani, N,et al."Noise effects in nonlinear biochemical signaling".PHYSICAL REVIEW E 85.1(2012):11901.
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