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Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy
Sun, Y; Cao, WP; Li, SL; Jin, SB; Hu, KL; Hu, LM; Huang, YY; Gao, XY; Wu, Y; Liang, XJ;高学云
2013
发表期刊SCIENTIFIC REPORTS
卷号3页码:3036
摘要Multifunctional nanoparticles as theranostic tools hold great potential for its unique and efficient way to visualize the process of disease treatment. However, the toxicity of conventional fluorescent labels and difficulty of functionalization limit their widespread use. Recently, a number of amino-rich polymers have demonstrated high luminescent fluorescence but rarely showed potential for in vivo imaging due to their blue fluorescence. Here, a general route has been found to construct polymer-based multifunctional nanoparticles for combined imaging and drug delivering. The weak fluorescent polyethyleneimine (PEI) has been conjugated with hydrophobic polylactide as the amphiphilic PEI for construction of nanoparticles which showed bright and multicolor fluorescence with high drug loading capacity. The paclitaxel-loaded nanoparticles showed significant therapy effect in contrast to the free paclitaxel. Meanwhile, fluorescence imaging of the nanoparticles showed accumulation around tumor. These results demonstrate a new type of polymer-based multifunctional nanoparticles for imaging-guided drug delivery.
学科领域Science & Technology - Other Topics
DOI10.1038/srep03036
收录类别SCI
WOS记录号WOS:000326031200001
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被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224469
专题多学科研究中心
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Sun, Y,Cao, WP,Li, SL,et al. Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy[J]. SCIENTIFIC REPORTS,2013,3:3036.
APA Sun, Y.,Cao, WP.,Li, SL.,Jin, SB.,Hu, KL.,...&Liang, XJ;高学云.(2013).Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy.SCIENTIFIC REPORTS,3,3036.
MLA Sun, Y,et al."Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy".SCIENTIFIC REPORTS 3(2013):3036.
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