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Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy
Yang, H; Sun, CJ; Fan, ZL; Tian, X; Yan, L; Du, LB; Liu, Y; Chen, CY; Liang, XJ; Anderson, GJ; Keelan, JA; Zhao, YL; Nie, GJ;晏亮; Zhao YL(赵宇亮)
2012
发表期刊SCIENTIFIC REPORTS
卷号2页码:847
摘要Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with different surface modifications (ferritin, PEG and citrate) following intravenous administration at E5.5-15.5. We showed that prior to E11.5, all tested nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, fetal gold levels declined dramatically post-E11.5. In contrast, Au-nanoparticle accumulation in the extraembryonic tissues (EET) increased 6-15 fold with gestational age. Fetal and EET accumulation of ferritin-and PEG-modified nanoparticles was considerably greater than citrate-capped nanoparticles. No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition.
学科领域Science & Technology - Other Topics
DOI10.1038/srep00847
收录类别SCI
WOS记录号WOS:000311100600001
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被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224442
专题多学科研究中心
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GB/T 7714
Yang, H,Sun, CJ,Fan, ZL,et al. Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy[J]. SCIENTIFIC REPORTS,2012,2:847.
APA Yang, H.,Sun, CJ.,Fan, ZL.,Tian, X.,Yan, L.,...&赵宇亮.(2012).Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy.SCIENTIFIC REPORTS,2,847.
MLA Yang, H,et al."Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy".SCIENTIFIC REPORTS 2(2012):847.
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