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Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study
Peng, HJ; Zheng, HR; Ning, YP; Zhang, Y; Shan, BC; Zhang, L; Yang, HC; Liu, J; Li, ZX; Zhou, JS; Zhang, ZJ; Li, LJ;单保慈
2013
发表期刊BMC PSYCHIATRY
卷号13页码:72
摘要Background: White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD. Approximately 30% of MDD patients demonstrate treatment-resistant depression (TRD). However, the neurobiology of TRD remains unclear. Methods: We used a voxel-based analysis method to analyze DTI data in young patients with TRD (n = 30; 19 males, 11 females) compared with right-handed, age- and sex-matched healthy volunteers (n = 25; 14 males, 11 females). Results: We found a significant decrease in fractional anisotropy (FA) (corrected, cluster size >50) in the left middle frontal gyrus (peak coordinates [-18 46-14]), left limbic lobe uncus (peak coordinates [-18 2-22]), and right cerebellum posterior lobe (peak coordinates [26-34 -40]). There was no increase in FA in any brain region in patients. We also found a significant negative correlation between mean regional FA values in the three areas and Beck Depression Inventory symptom scores. Conclusions: We found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. These data suggest that abnormalities of cortical-limbic-cerebellar white matter networks may contribute to TRD in young patients.
关键词Treatment-resistant depression Diffusion tensor imaging Fractional anisotropy Voxel-based analysis method
学科领域Psychiatry
DOI10.1186/1471-244X-13-72
收录类别SCI
WOS记录号WOS:000316270300001
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被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224412
专题核技术应用研究中心
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GB/T 7714
Peng, HJ,Zheng, HR,Ning, YP,et al. Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study[J]. BMC PSYCHIATRY,2013,13:72.
APA Peng, HJ.,Zheng, HR.,Ning, YP.,Zhang, Y.,Shan, BC.,...&Li, LJ;单保慈.(2013).Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study.BMC PSYCHIATRY,13,72.
MLA Peng, HJ,et al."Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study".BMC PSYCHIATRY 13(2013):72.
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