Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging
Xu, ZZ; Liao, Q; Wu, YS; Ren, WL; Li, W; Liu, LB; Wang, S; Gu, ZJ; Zhang, HL; Fu, HB;任文璐; 李炜(多); Gu ZJ(谷战军)
刊名JOURNAL OF MATERIALS CHEMISTRY
2012
卷号22期号:34页码:17737-17743
学科分类Chemistry; Materials Science
DOI10.1039/c2jm33081d
英文摘要Many two-photon absorption (TPA) organic dyes are water insoluble and suffer from strong fluorescence quenching in aqueous media due to the self-aggregation effect. This seriously limits their applications as two-photon fluorescence (TPF) probes in bio-imaging. By employing a reprecipitation method, we prepared ultrabright water-miscible organic nanoparticles (ONPs) of 1,4-dimethoxy-2,5-di[4'-(cyano)styryl]benzene (COPV). The single-crystal structure reveals that the cooperation between pi-pi stacking and hydrogen-bonding interactions drives COPV molecules into a brickwork arrangement of J-aggregates, in which the coherent excitation delocalization reaches 2-3 molecules. Due to the superradiance of J-aggregates, COPV ONPs are highly emissive in aqueous media with a quantum yield >0.4; meanwhile, their TPA cross-section is greatly enhanced, probably due to exciton-vibration coupling. As TPF probes, COPV J-aggregate ONPs are 3-4 orders of magnitude brighter than conventional fluorescent dyes and an order of magnitude brighter than quantum dots. Moreover, these ONPs exhibit no obvious cytotoxicity at concentrations as high as 100 mu g mL(-1). Our results demonstrate that ultrabright J-aggregate ONPs of COPV provide a new strategy to construct efficient TPF nano-probes for bio-imaging.
收录类别SCI
WOS记录号WOS:000307305700050
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224357
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Xu, ZZ,Liao, Q,Wu, YS,et al. Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(34):17737-17743.
APA Xu, ZZ.,Liao, Q.,Wu, YS.,Ren, WL.,Li, W.,...&谷战军.(2012).Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging.JOURNAL OF MATERIALS CHEMISTRY,22(34),17737-17743.
MLA Xu, ZZ,et al."Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging".JOURNAL OF MATERIALS CHEMISTRY 22.34(2012):17737-17743.
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