Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes
Wang LM(王黎明); Li JY(李敬源); Pan J(潘俊); Wang, LM; Li, JY; Pan, J; Jiang, XM; Ji, YL; Li, YF; Qu, Y; Zhao, YL; Wu, XC; Chen, CY; Jiang XM(蒋秀梅); Li YF(李玉锋); Ju Y(瞿颖); Zhao YL(赵宇亮); Chen CY(陈春英)
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2013
卷号135期号:46页码:17359-17368
学科分类Chemistry
DOI10.1021/ja406924v
英文摘要Regarding the importance of the biological effects of nanomaterials, there is still limited knowledge about the binding structure and stability of the protein corona on nanomaterials and the subsequent impacts. Here we designed a hard serum albumin protein corona (BSA) on CTAB-coated gold nanorods (AuNRs) and captured the structure of protein adsorption using synchrotron radiation X-ray absorption spectroscopy, microbeam X-ray fluorescent spectroscopy, and circular dichroism in combination with molecular dynamics simulations. The protein adsorption is attributed to at least 12 Au-S bonds and the stable corona reduced the cytotoxicity of CTAB/AuNRs. These combined strategies using physical, chemical, and biological approaches will improve our understanding of the protective effects of protein coronas against the toxicity of nanomaterials. These findings have shed light on a new strategy for studying interactions between proteins and nanomaterials, and this information will help further guide the rational design of nanomaterials for safe and effective biomedical applications.
收录类别SCI
WOS记录号WOS:000327413300025
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224355
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Wang LM,Li JY,Pan J,et al. Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(46):17359-17368.
APA 王黎明.,李敬源.,潘俊.,Wang, LM.,Li, JY.,...&陈春英.(2013).Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(46),17359-17368.
MLA 王黎明,et al."Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.46(2013):17359-17368.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
7826.pdf(859KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[王黎明]的文章
[李敬源]的文章
[潘俊]的文章
百度学术
百度学术中相似的文章
[王黎明]的文章
[李敬源]的文章
[潘俊]的文章
必应学术
必应学术中相似的文章
[王黎明]的文章
[李敬源]的文章
[潘俊]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 7826.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。