IHEP OpenIR  > 多学科研究中心
A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells
Jin S(金珊); Zhou LJ(周良军); Gu ZJ(谷战军); Jin, S; Zhou, LJ; Gu, ZJ; Tian, G; Yan, L; Ren, WL; Yin, WY; Liu, XD; Zhang, X; Hu, ZB; Zhao, YL; Tian G(田甘); Yan L(晏亮); Ren WL(任文璐); Yin WY(尹文艳); Liu XD(刘晓东); Zhang X(张笑); Zhao YL(赵宇亮)
2013
发表期刊NANOSCALE
卷号5期号:23页码:11910-11918
摘要The utilization of up-conversion nanoparticles (UCNPs) for photodynamic therapy (PDT) has gained significant interest due to their unique ability to convert near infrared light to UV/visible light. Previous work mainly focused on the fabrication of green and red emitting UCNPs to load photosensitizers (PSs) for PDT. In this work, we firstly developed a new multifunctional nanoplatform combining blue-emitting UCNPs with blue-light excited PS (hypocrellin A, HA) as a NIR photosensitizing nanoplatform for PDT of cancer cells. Tween 20 coated NaYbF4:Tm, Gd@NaGdF4 UCNPs (Tween 20-UCNPs) with strong blue up-conversion luminescence and good water dispersibility were prepared for use as PS carriers. The blue emission band matched well with the efficient absorption band of HA, thereby facilitating the resonance energy transfer from UCNPs to HA and then activating HA to produce singlet oxygen (O-1(2)). The in vitro study showed that these Tween 20-UCNPs@HA complexes could efficiently produce O-1(2) to kill cancer cells under 980 nm NIR excitation. Moreover, these Gd3+ and Yb3+ containing nanoparticles also exhibited positive contrast effects in both T-1 weighted magnetic resonance imaging (MRI) and computed tomography (CT) imaging, making them become a multifunctional platform for simultaneous PDT and bio-imaging.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c3nr03515h
收录类别SCI
WOS记录号WOS:000326982000070
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224337
专题多学科研究中心
推荐引用方式
GB/T 7714
Jin S,Zhou LJ,Gu ZJ,et al. A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells[J]. NANOSCALE,2013,5(23):11910-11918.
APA 金珊.,周良军.,谷战军.,Jin, S.,Zhou, LJ.,...&赵宇亮.(2013).A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells.NANOSCALE,5(23),11910-11918.
MLA 金珊,et al."A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells".NANOSCALE 5.23(2013):11910-11918.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
7788.pdf(918KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[金珊]的文章
[周良军]的文章
[谷战军]的文章
百度学术
百度学术中相似的文章
[金珊]的文章
[周良军]的文章
[谷战军]的文章
必应学术
必应学术中相似的文章
[金珊]的文章
[周良军]的文章
[谷战军]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 7788.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。