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Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity
Wang LM(王黎明); Jiang XM(江秀梅); Wang, LM; Jiang, XM; Ji, YL; Bai, R; Zhao, YL; Wu, XC; Chen, CY; Bai R(白茹); Zhao YL(赵宇亮); Chen CY(陈春英)
2013
发表期刊NANOSCALE
卷号5期号:18页码:8384-8391
摘要We investigated how surface chemistry influences the interaction between gold nanorods (AuNRs) and cell membranes and the subsequent cytotoxicity arising from them in a serum-free cell culture system. Our results showed that the AuNRs coated with cetyl trimethylammonium bromide (CTAB) molecules can generate defects in the cell membrane and induce cell death, mainly due to the unique bilayer structure of CTAB molecules on the surface of the rods rather than their charge. Compared to CTAB-capped nanorods, positively charged polyelectrolyte-coated, i.e. poly(diallyldimethyl ammonium chloride) (PDDAC), AuNRs show improved biocompatibility towards cells. Thus, the present results indicate that the nature of surface molecules, especially their packing structures on the surface of AuNRs rather than surface charge, play a more crucial role in determining cytotoxicity. These findings about interfacial interactions could also explain the effects of internalized AuNRs on the structures or functions of organelles. This study will help understanding of the toxic nature of AuNRs and guide rational design of the surface chemistry of AuNRs for good biocompatibility in pharmaceutical therapy.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c3nr01626a
收录类别SCI
WOS记录号WOS:000323521000013
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224308
专题多学科研究中心
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GB/T 7714
Wang LM,Jiang XM,Wang, LM,et al. Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity[J]. NANOSCALE,2013,5(18):8384-8391.
APA 王黎明.,江秀梅.,Wang, LM.,Jiang, XM.,Ji, YL.,...&陈春英.(2013).Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity.NANOSCALE,5(18),8384-8391.
MLA 王黎明,et al."Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity".NANOSCALE 5.18(2013):8384-8391.
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