Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules
Yin XH(尹晓慧); Zhao LN(赵丽娜); Yin, XH; Zhao, LN; Kang, SG; Pan, J; Song, Y; Zhang, MY; Xing, GM; Wang, F; Li, JY; Zhou, RH; Zhao, YL; Pan J(潘俊); Song Y(宋炎); Zhang MY(张铭倚); Xing GM(邢更妹); Li JY(李敬源); Zhao YL(赵宇亮)
刊名NANOSCALE
2013
卷号5期号:16页码:7341-7348
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c3nr01469j
英文摘要During cancer development, the fibrous layers surrounding the tumor surface get thin and stiff which facilitates the tumor metastasis. After the treatment of metallofullerene derivatives Gd@C-82(OH)(22), the fibrous layers become thicker and softer, the metastasis of tumor is then largely suppressed. The effect of Gd@C-82(OH)(22) was found to be related to their direct interaction with collagen and the resulting impact on the structure of collagen fibrils, the major component of extracellular matrices. In this work we study the interaction of Gd@C-82(OH)(22) with collagen by molecular dynamics simulations. We find that Gd@C-82(OH)(22) can enhance the rigidity of the native structure of collagen molecules and promote the formation of an oligomer or a microfibril. The interaction with Gd@C-82(OH)(22) may regulate further the assembly of collagen fibrils and change the biophysical properties of collagen. The control run with fullerene derivatives C-60(OH)(24) also indicates that C-60(OH)(24) can influence the structure and assembly of collagen molecules as well, but to a lesser degree. Both fullerene derivatives can form hydrogen bonds with multiple collagen molecules acting as a "fullerenol-mediated bridge" that enhance the interaction within or among collagen molecules. Compared to C-60(OH)(24), the interaction of Gd@C-82(OH)(22) with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils.
收录类别SCI
WOS记录号WOS:000322315600031
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224296
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Yin XH,Zhao LN,Yin, XH,et al. Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules[J]. NANOSCALE,2013,5(16):7341-7348.
APA 尹晓慧.,赵丽娜.,Yin, XH.,Zhao, LN.,Kang, SG.,...&赵宇亮.(2013).Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules.NANOSCALE,5(16),7341-7348.
MLA 尹晓慧,et al."Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules".NANOSCALE 5.16(2013):7341-7348.
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