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Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore
Yang C(杨纯); Liu L(刘蕾); Yang, C; Liu, L; Zeng, T; Yang, DW; Yao, ZY; Zhao, YL; Wu, HC;; Yao ZY(姚志轶); Zhao YL(赵宇亮); Wu HC(吴海臣)
2013
发表期刊ANALYTICAL CHEMISTRY
卷号85期号:15页码:7302-7307
摘要Both Pb2+ and Ba2+ can bind with high affinity to some specific DNA sequences, inducing the formation of unimolecular G-quadruplex structures. Trans location of a DNA probe containing such sequences through an alpha-hemolysin nanopore in the presence of Pb2+ or Ba2+ . would result in much prolonged DNA translocation events. Quantification of these events can reveal the concentrations of Pb2+ or Ba2+ at as low as 0.8 nM. Besides, Pb2+ and Ba2+ in the solution can be simultaneously detected and individually identified. Furthermore, the probe is highly selective for Pb2+ and Ba2+ detection without interference from other metal ions. This sensing strategy can be extended to many other analytes which can bind to DNA molecules with high affinity.
学科领域Chemistry
DOI10.1021/ac401198d
收录类别SCI
WOS记录号WOS:000323014000046
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224295
专题多学科研究中心
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GB/T 7714
Yang C,Liu L,Yang, C,et al. Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore[J]. ANALYTICAL CHEMISTRY,2013,85(15):7302-7307.
APA 杨纯.,刘蕾.,Yang, C.,Liu, L.,Zeng, T.,...&吴海臣.(2013).Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore.ANALYTICAL CHEMISTRY,85(15),7302-7307.
MLA 杨纯,et al."Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore".ANALYTICAL CHEMISTRY 85.15(2013):7302-7307.
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