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The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways
Zhou, HJ; Zhao, K; 李炜(多); 陈春英;Li, W; Yang, N; Liu, Y; Chen, CY; Wei, TT
2012
发表期刊BIOMATERIALS
卷号33期号:29页码:6933-6942
摘要Graphene may have attractive properties for some biomedical applications, but its potential adverse biological effects, in particular, possible modulation of immune responses, require further investigation. Macrophages are one of the most important effector cells of the innate immune system, and play pivotal roles in the response to graphene exposure. We have previously reported that exposure of macrophages to high concentrations of graphene triggers cell death via MAPK- and TGF-related pathways. However, little is known about the influence of exposure to low concentrations of graphene on the function of macrophages. In the present investigation, we demonstrate the biological effects of sub-cytotoxic concentrations of commercial pristine graphene on both primary murine macrophages and immortalized macrophages. Graphene significantly stimulates the secretion of Th1/Th2 cytokines including IL-1 alpha, IL-6, IL-10, TNF-alpha and GM-CSF as well as chemokines such as MCP-1, MIP-1 alpha, MIP-1 beta and RANTES, probably by activating TLR-mediated and NF-kappa B-dependent transcription. Furthermore, these graphene-induced factors alter the morphology of naive macrophages by remodeling their actin assembly, decreasing their ability to adhere to the extracellular matrix, and attenuating their phagocytosis. This negative feedback of the immune response of macrophages by graphene-induced factors may play an important role in the prevention of their over-activation after graphene exposure. These findings shed light on the interaction of graphene and macrophages in vitro. Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Graphene Macrophage Cytokines Chemokines NF-kappa B Innate immune system
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2012.06.064
收录类别SCI
WOS记录号WOS:000308269600004
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224285
专题多学科研究中心
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GB/T 7714
Zhou, HJ,Zhao, K,Li W,et al. The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways[J]. BIOMATERIALS,2012,33(29):6933-6942.
APA Zhou, HJ.,Zhao, K.,李炜.,陈春英;Li, W.,Yang, N.,...&Wei, TT.(2012).The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways.BIOMATERIALS,33(29),6933-6942.
MLA Zhou, HJ,et al."The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways".BIOMATERIALS 33.29(2012):6933-6942.
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