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Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation
Xue LX(薛凌喜); He X(何萧); Li YY(李媛媛); 张智勇;Xue, LX; He, X; Li, YY; Qu, MH; Zhang, ZY
2013
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号13期号:10页码:6575-6580
摘要Ceria nanoparticles (nano-ceria) are widely used for various applications such as catalytic converters for automobile exhaust, ultraviolet absorber, and electrolyte in fuel cells. Their potential impacts on the environment and human health have also drawn people's attention. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after an acute intratracheal instillation. CD-1 mice were exposed to 0.04, 0.4, 4 and 40 mu g nano-ceria (corresponding to 10, 100, 1000 and 10000 times of the maximum exposure dose, respectively) and sacrificed at 1, 7, and 28 d post-exposure. Lung injury was assessed by bronchoalveolar ravage fluid (BALF) analysis, cell counts, biochemical analysis of lung homogenate, and histopathology. Cell differential analysis of the BALF show that the numbers of neutrophils and lymphocytes increased significantly in the mice exposed to 40 mu g nano-ceria at 1 d after instillation, and returned to control levels by 7 d. The lactate dehydrogenate activity in the BALF from the 40 mu g group increased significantly during the whole experimental period. Pathological changes were only found in the lung tissues from the mice of 40 mu g nano-ceria group. The changes were most obvious by 7 d post-exposure, and returned to normal by 28 d. No other changes were found. The results of the present study suggest that exposure to nano-ceria at the current levels in the ambient air may not cause respiratory toxicity.
关键词Ceria Nanoparticles Pulmonary Toxicity Intratracheal Instillation
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.7216
收录类别SCI
WOS记录号WOS:000328704000014
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224281
专题粒子天体物理中心
多学科研究中心
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GB/T 7714
Xue LX,He X,Li YY,et al. Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(10):6575-6580.
APA 薛凌喜.,何萧.,李媛媛.,张智勇;Xue, LX.,He, X.,...&Zhang, ZY.(2013).Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(10),6575-6580.
MLA 薛凌喜,et al."Pulmonary Toxicity of Ceria Nanoparticles in Mice After Intratracheal Instillation".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.10(2013):6575-6580.
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