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A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma
Tian, X; Zhu, MT; Tian, YH; Ramm, GA; Zhao, YL; Nie, GJ;赵宇亮
2012
发表期刊BIOMATERIALS
卷号33期号:26页码:6147-6154
摘要In the past few years, cell-derived membrane vesicle-based tumor vaccines have been considered as valuable new tools for cancer immunotherapy. Despite promising results in cancer clinical trails, an improved method is urgently needed for high efficiency tumor vaccines for a broad spectrum of tumors. Here we developed a single membrane vesicle-based vaccine, which is active in repressing both melanoma (B16) and Lewis lung carcinoma (LLC) tumor growth. By using the intrinsic function of dendritic cells in the processing and presentation of antigens, we generated dendritic cell (DC)-derived membrane vesicles (DC-mv) bearing tumor antigens from both B16 and LLC cells. Vaccination with this DC-mv-based dual vaccine induced specific cytotoxic T lymphocytes (CTL)-dependent tumor rejection and suppressed the growth of both types of tumor xenografts in mice. In addition, induction of CTL by this vaccine resulted in cross-protection responses and consequently enabled significant enhanced anti-tumor effects, indicating the synergistic anti-tumor activity. Our study suggests that the DC-mv-based vaccine holds great potential as a highly effective, versatile, cell-free vaccine for inhibition of multiple types of tumor growth. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Membrane vesicle Anti-Tumor dual vaccine Synergistic effect Cancer immunotherapy
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2012.05.034
收录类别SCI
WOS记录号WOS:000306720400018
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224275
专题多学科研究中心
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GB/T 7714
Tian, X,Zhu, MT,Tian, YH,et al. A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma[J]. BIOMATERIALS,2012,33(26):6147-6154.
APA Tian, X,Zhu, MT,Tian, YH,Ramm, GA,Zhao, YL,&Nie, GJ;赵宇亮.(2012).A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma.BIOMATERIALS,33(26),6147-6154.
MLA Tian, X,et al."A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma".BIOMATERIALS 33.26(2012):6147-6154.
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