IHEP OpenIR  > 多学科研究中心
A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells
Zhang, XY; He X(何潇); Li YY(李媛媛); Zhang ZY(张智勇); 马宇辉;He, X; Li, YY; Zhang, ZY; Ma, YH; Li, FM; Liu, JM
2013
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
EISSN1533-4899
Volume13Issue:8Pages:5254-5259
AbstractThe labeling of living cells with carbon nanoparticles has been increasingly studied both in vivo and in vitro, but concerns about the potential cytotoxicity of these nanoprobes are also increasing. In this study, the fluorescent carbon dots (CDs) without surface modification was synthesized and evaluated for its cytotoxicity. Indicators including cell viability, total reactive oxygen species (ROS), glutathione, malondialdehyde and lactate dehydrogenase were assessed using human bronchial epithelial (16HBE) cell line. Our results showed that CDs preferred to locate on the surface of cells, which significantly increased the membrane permeability of 16HBE cells. CDs exposure could further induce oxidative stress, exhaust the antioxidant defenses of cells and finally lead to decreased cell viability. Therefore, surface modification of CDs is needed to minimize its cytotoxicity. The present work is useful for the development of new strategies towards the in vitro and in vivo applications of CDs for optical imaging and drug delivery.
KeywordCarbon Dots Cytotoxicity Membrane Injury Oxidative Damage
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.7528
Indexed BySCI
Language英语
WOS IDWOS:000320632200005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/224256
Collection多学科研究中心
Recommended Citation
GB/T 7714
Zhang, XY,He X,Li YY,et al. A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(8):5254-5259.
APA Zhang, XY.,何潇.,李媛媛.,张智勇.,马宇辉;He, X.,...&Liu, JM.(2013).A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(8),5254-5259.
MLA Zhang, XY,et al."A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.8(2013):5254-5259.
Files in This Item:
File Name/Size DocType Version Access License
7500.pdf(4280KB)期刊论文作者接受稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, XY]'s Articles
[何潇]'s Articles
[李媛媛]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, XY]'s Articles
[何潇]'s Articles
[李媛媛]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, XY]'s Articles
[何潇]'s Articles
[李媛媛]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.