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A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells
Zhang, XY; He X(何潇); Li YY(李媛媛); Zhang ZY(张智勇); 马宇辉;He, X; Li, YY; Zhang, ZY; Ma, YH; Li, FM; Liu, JM
2013
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号13期号:8页码:5254-5259
摘要The labeling of living cells with carbon nanoparticles has been increasingly studied both in vivo and in vitro, but concerns about the potential cytotoxicity of these nanoprobes are also increasing. In this study, the fluorescent carbon dots (CDs) without surface modification was synthesized and evaluated for its cytotoxicity. Indicators including cell viability, total reactive oxygen species (ROS), glutathione, malondialdehyde and lactate dehydrogenase were assessed using human bronchial epithelial (16HBE) cell line. Our results showed that CDs preferred to locate on the surface of cells, which significantly increased the membrane permeability of 16HBE cells. CDs exposure could further induce oxidative stress, exhaust the antioxidant defenses of cells and finally lead to decreased cell viability. Therefore, surface modification of CDs is needed to minimize its cytotoxicity. The present work is useful for the development of new strategies towards the in vitro and in vivo applications of CDs for optical imaging and drug delivery.
关键词Carbon Dots Cytotoxicity Membrane Injury Oxidative Damage
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.7528
收录类别SCI
WOS记录号WOS:000320632200005
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224256
专题多学科研究中心
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GB/T 7714
Zhang, XY,He X,Li YY,et al. A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(8):5254-5259.
APA Zhang, XY.,何潇.,李媛媛.,张智勇.,马宇辉;He, X.,...&Liu, JM.(2013).A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(8),5254-5259.
MLA Zhang, XY,et al."A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.8(2013):5254-5259.
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