IHEP OpenIR  > 核技术应用研究中心
Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder
Ye T(叶婷); Ye, T; Nie BB(聂彬彬); Peng, J; Nie, BB; Gao, J; Liu, JT; Li, Y; Wang, G; Ma, X; Li, KC; Shan, BC;; Gao J(高娟); Dan BC(单保慈)
2012
发表期刊EUROPEAN JOURNAL OF RADIOLOGY
卷号81期号:12页码:4035-4040
摘要Background: The aim of this study was to investigate resting-state functional connectivity alteration of the right dorsolateral prefrontal cortex (DLPFC) in patients with first-episode major depressive disorder (MDD). Methods: Twenty-two first-episode MDD patients and thirty age-, gender-and education-matched healthy control subjects were enrolled. Rest state functional magnetic resonance images and structure magnetic resonance images were scanned. The functional connectivity analysis was done based on the result of voxel-based morphometry (VBM). And the right DLPFC was chosen as the seed region of interests (ROI), as its gray matter density (GMD) decreased in the MDD patients compared with controls and its GMD values were negative correlation with the Hamilton Depression Rating Scale (HDRS) scores. Results: Compared to healthy controls, the MDD patients showed increased functional connectivity with right the DLPFC in the left dorsal anterior cingulate cortex (ACC), left parahippocampal gyrus (PHG), thalamus and precentral gyrus. In contrast, there were decreased functional connectivity between the right DLPFC and right parietal lobe. Conclusions: By applying the VBM results to the functional connectivity analysis, the study suggested that abnormality of GMD in right DLPFC might be related to the functional connectivity alteration in the pathophysiology of MDD, which might be useful in further characterizing structure-function relations in this disorder. (C) 2012 Published by Elsevier Ireland Ltd.
关键词Major depressive disorder Functional connectivity Dorsolateral prefrontal cortex Voxel-based morphometry
学科领域Radiology, Nuclear Medicine & Medical Imaging
DOI10.1016/j.ejrad.2011.04.058
收录类别SCI
WOS记录号WOS:000311340800055
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224249
专题核技术应用研究中心
推荐引用方式
GB/T 7714
Ye T,Ye, T,Nie BB,et al. Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder[J]. EUROPEAN JOURNAL OF RADIOLOGY,2012,81(12):4035-4040.
APA 叶婷.,Ye, T.,聂彬彬.,Peng, J.,Nie, BB.,...&单保慈.(2012).Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder.EUROPEAN JOURNAL OF RADIOLOGY,81(12),4035-4040.
MLA 叶婷,et al."Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder".EUROPEAN JOURNAL OF RADIOLOGY 81.12(2012):4035-4040.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
7404.pdf(637KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[叶婷]的文章
[Ye, T]的文章
[聂彬彬]的文章
百度学术
百度学术中相似的文章
[叶婷]的文章
[Ye, T]的文章
[聂彬彬]的文章
必应学术
必应学术中相似的文章
[叶婷]的文章
[Ye, T]的文章
[聂彬彬]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。