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Simulation Study on Gold Nanoparticle-Cellular Membrane Complex in Endocytosis Process
Zheng FX(郑凤仙); Pan J(潘俊); Yin XH(尹晓慧); Zheng, FX; Pan, J; Yin, XH; Li, JY; Wang, F; Zhao, LN;; Li JY(李敬源); Zhao LN(赵丽娜)
2013
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号13期号:6页码:3990-3998
摘要Gold nanoparticles (AuNPs) are of biomedical importance, such as delivery vectors. Therefore, we used all-atom molecular dynamic simulations to study the interaction of AuNPs with cell membrane (DMPC bilayer). We observed that the AuNPs adhered spontaneously on the surface of the cellular membrane from the bulk phase, largely as a result of the AuNP-DMPC headgroup attraction. We calculated the potential of mean force for transferring an AuNP through a DMPC bilayer. It was observed that a high energetic barrier to AuNP was inserted into the hydrophobic core of the bilayer. The inclusion of AuNP induced local bilayer deformation and slowed fluidity of the lipid molecules in the vicinity of it. As the size of the AuNP increased, the lipids in the vicinity of the AuNP had larger local deformation and slower fluidity. We found that a nanoparticle-membrane complex was formed by the AuNP and its neighbor lipids. These neighbor lipids moved laterally together with AuNP. On average, they moved significantly more slowly than the other lipids. The nanoparticle-membrane complex not only provided a clue for endocytosis mechanism regulating the translocation of AuNPs across the cellular membrane but also helped us to better understand the endocytosis process.
关键词Gold Nanoparticle Cellular Membrane Endocytosis Process Molecular Dynamics Simulation
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.7225
收录类别SCI
WOS记录号WOS:000320205400034
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224248
专题多学科研究中心
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Zheng FX,Pan J,Yin XH,et al. Simulation Study on Gold Nanoparticle-Cellular Membrane Complex in Endocytosis Process[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(6):3990-3998.
APA 郑凤仙.,潘俊.,尹晓慧.,Zheng, FX.,Pan, J.,...&赵丽娜.(2013).Simulation Study on Gold Nanoparticle-Cellular Membrane Complex in Endocytosis Process.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(6),3990-3998.
MLA 郑凤仙,et al."Simulation Study on Gold Nanoparticle-Cellular Membrane Complex in Endocytosis Process".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.6(2013):3990-3998.
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