Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications
Gu ZJ(谷战军); Yan L(晏亮); Tian G(田甘); 赵宇亮;Gu, ZJ; Yan, L; Tian, G; Li, SJ; Chai, ZF; Zhao, YL
刊名ADVANCED MATERIALS
2013
卷号25期号:SI28页码:3758-3779
关键词upconversion nanoparticles multifunction bioimaging drug delivery nanoprobes
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/adma.201301197
英文摘要Lanthanide (Ln) doped upconversion nanoparticles (UCNPs) have attracted enormous attention in the recent years due to their unique upconversion luminescent properties that enable the conversion of low-energy photons (near infrared photons) into high-energy photons (visible to ultraviolet photons) via the multiphoton processes. This feature makes them ideal for bioimaging applications with attractive advantages such as no autofluorescence from biotissues and a large penetration depth. In addition, by incorporating advanced features, such as specific targeting, multimodality imaging and therapeutic delivery, the application of UCNPs has been dramatically expanded. In this review, we first summarize the recent developments in the fabrication strategies of UCNPs with the desired size, enhanced and tunable upconversion luminescence, as well as the combined multifunctionality. We then discuss the chemical methods applied for UCNPs surface functionalization to make these UCNPs biocompatible and water-soluble, and further highlight some representative examples of using UCNPs for in vivo bioimaging, NIR-triggered drug/gene delivery applications and photodynamic therapy. In the perspectives, we discuss the need of systematically nanotoxicology data for rational designs of UCNPs materials, their surface chemistry in safer biomedical applications. The UCNPs can actually provide an ideal multifunctionalized platform for solutions to many key issues in the front of medical sciences such as theranostics, individualized therapeutics, multimodality medicine, etc.
收录类别SCI
WOS记录号WOS:000327749400002
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被引频次:218[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224244
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Gu ZJ,Yan L,Tian G,et al. Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications[J]. ADVANCED MATERIALS,2013,25(SI28):3758-3779.
APA 谷战军.,晏亮.,田甘.,赵宇亮;Gu, ZJ.,Yan, L.,...&Zhao, YL.(2013).Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications.ADVANCED MATERIALS,25(SI28),3758-3779.
MLA 谷战军,et al."Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications".ADVANCED MATERIALS 25.SI28(2013):3758-3779.
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