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Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations
Zhang HF(张海峰); He X(何潇); Zhang ZY(张智勇); Zhang, HF; He, XA; Zhang, ZY; Zhang, P; Li, YY; Ma, YH; Kuang, YS; Zhao, YL; Chai, ZF;; 张鹏(多); Li YY(李媛媛); Ma YH(马宇辉); Yashu Kuang; Zhao YL(赵宇亮); Chai ZF(柴之芳)
AbstractCeria nanoparticles (nano-CeO2), due to their widespread applications, have attracted a lot of concern about their toxic effects on both human health and the environment. The present work aimed to evaluate the in vivo effects of nano-CeO2 (8.5 nm) on Caenorhabditis elegans (C. elegans) at environmental relevant concentrations (molar concentrations ranging from 1 nM to 100 nM). The results indicate that nano-CeO2 could induce ROS accumulation and oxidative damage in C. elegans, and finally lead to a decreased lifespan. The most surprising thing is that the mean lifespan of nematodes was significantly decreased by 12% even at the exposure level of 1 nM (p < 0.01). In vitro tests suggest that the ability of nano-CeO2 to catalyze ROS generation was involved in the mechanism for its toxicity to C. elegans. To our best knowledge, this is the first case in which nanoparticles exhibit adverse effects on organisms at such low concentrations (1 nM-100 nM). So, our findings indicate the importance of nanotoxicological investigations at: environmentally relevant concentrations and will attract more attentions on the risks of NPs exposure.
Subject AreaEngineering; Environmental Sciences & Ecology
Indexed BySCI ; ADS
WOS IDWOS:000289341300075
ADS Bibcode2011EnST...45.3725Z
ADS URLhttps://ui.adsabs.harvard.edu/abs/2011EnST...45.3725Z
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2011EnST...45.3725Z/citations
Citation statistics
Cited Times:43 [ADS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Zhang HF,He X,Zhang ZY,et al. Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2011,45(8):3725-3730.
APA 张海峰.,何潇.,张智勇.,Zhang, HF.,He, XA.,...&柴之芳.(2011).Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations.ENVIRONMENTAL SCIENCE & TECHNOLOGY,45(8),3725-3730.
MLA 张海峰,et al."Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations".ENVIRONMENTAL SCIENCE & TECHNOLOGY 45.8(2011):3725-3730.
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