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Structural peculiarities of the (MHF1-MHF2)(4) octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study
Wang WJ(王文佳); Wang, WJ; Guo, Q; Shtykova, EV; Liu, GF; Xu, JH; Teng, MK; Liu, P; Dong, YH;; Liu GF(刘广峰); Xu JH(徐建华); 刘鹏(多); Dong YH(董宇辉)
2013
发表期刊FEBS LETTERS
卷号587期号:18页码:2912-2917
摘要MHF1 and MHF2 are histone-fold-containing FANCM-associated proteins. FANCM is a Fanconi anemia (FA) complementation group protein. We previously obtained high-resolution structures of MHF1-MHF2 (MHF) and MHF in complex with a fragment of FANCM (MHF-FANCM-F). Here, we use small angle X-ray scattering (SAXS) to investigate the solution behaviors of these protein complexes. In combination with crystallographic data, the results of the SAXS study reveal that a long, positively charged patch exposed on the surface of the MHF complex plays a critical role in double-stranded DNA (dsDNA) binding. Structured summary of protein interactions: MHF2, MHF1 and FANCM-F physically interact by molecular sieving (View interaction) MHF1 and MHF2 bind by X ray scattering (View interaction) MHF1 and MHF2 bind by molecular sieving (View interaction) MHF1, FANCM-F and MHF2 physically interact by X ray scattering (View interaction) (C) 2013 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
关键词Fanconi anaemia MHF complex FANCM DNA binding patch SAXS
学科领域Biochemistry & Molecular Biology; Biophysics; Cell Biology
DOI10.1016/j.febslet.2013.07.022
收录类别SCI
WOS记录号WOS:000324033700003
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224217
专题多学科研究中心
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GB/T 7714
Wang WJ,Wang, WJ,Guo, Q,et al. Structural peculiarities of the (MHF1-MHF2)(4) octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study[J]. FEBS LETTERS,2013,587(18):2912-2917.
APA 王文佳.,Wang, WJ.,Guo, Q.,Shtykova, EV.,Liu, GF.,...&董宇辉.(2013).Structural peculiarities of the (MHF1-MHF2)(4) octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study.FEBS LETTERS,587(18),2912-2917.
MLA 王文佳,et al."Structural peculiarities of the (MHF1-MHF2)(4) octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study".FEBS LETTERS 587.18(2013):2912-2917.
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