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Controllable synthesis of Gd2O(CO3)(2)center dot H2O@silica-FITC nanoparticles with size-dependent optical and magnetic resonance imaging properties
Zhou LJ(周亮君); Yin WY(尹文艳); Ren WL(任文璐); Zhou, LJ; Yin, WY; Ren, WL; Gu, ZJ; Li, W; Jin, S; Yan, L; Tian, G; Hu, ZB; Zhao, YL; Gu ZJ(谷战军); 李炜(多); Jin S(金珊); Yan L(晏亮); Tian G(田甘); Zhao YL(赵宇亮)
2012
发表期刊NEW JOURNAL OF CHEMISTRY
卷号36期号:12页码:2599-2606
摘要Gadolinium carbonate (Gd2O(CO3)(2)center dot H2O) nanoparticles (NPs) with different diameters (from 280 nm to 10 nm) were obtained through a simple hydrothermal process by adding different volumes of glycerol. These Gd2O(CO3)(2)center dot H2O NPs were further coated with a thin layer of silica containing fluorescent dye (fluorescein isothiocyanate, FITC), and the possibility of using these NPs for optical imaging was demonstrated. In addition, due to the presence of Gd3+ ions on the surface of the NPs, magnetic resonance imaging (MRI) of Gd2O(CO3)(2)center dot H2O NPs with different diameters was also reported in detail. Considering the effect of NPs' size on their biocompatibility and MRI properties, our research results indicated that the Gd2O(CO3)(2)center dot H2O NPs of 50 nm showed the highest cytotoxicity and the maximum uptake by cells, and the MRI properties of Gd2O(CO3)(2)center dot H2O@silica-FITC NPs are also size-dependent. Therefore, these NPs exhibit bifunctionality for both optical imaging and MRI, making them potentially applicable in the biomedical field.
学科领域Chemistry
DOI10.1039/c2nj40431a
收录类别SCI
WOS记录号WOS:000311971400024
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224208
专题多学科研究中心
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Zhou LJ,Yin WY,Ren WL,et al. Controllable synthesis of Gd2O(CO3)(2)center dot H2O@silica-FITC nanoparticles with size-dependent optical and magnetic resonance imaging properties[J]. NEW JOURNAL OF CHEMISTRY,2012,36(12):2599-2606.
APA 周亮君.,尹文艳.,任文璐.,Zhou, LJ.,Yin, WY.,...&赵宇亮.(2012).Controllable synthesis of Gd2O(CO3)(2)center dot H2O@silica-FITC nanoparticles with size-dependent optical and magnetic resonance imaging properties.NEW JOURNAL OF CHEMISTRY,36(12),2599-2606.
MLA 周亮君,et al."Controllable synthesis of Gd2O(CO3)(2)center dot H2O@silica-FITC nanoparticles with size-dependent optical and magnetic resonance imaging properties".NEW JOURNAL OF CHEMISTRY 36.12(2012):2599-2606.
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