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Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species
Yan L(晏亮); Gu ZJ(谷战军); 赵宇亮;Yan, L; Gu, ZJ; Zhao, YL
2013
发表期刊CHEMISTRY-AN ASIAN JOURNAL
卷号8期号:SI10页码:2342-2353
摘要As more and more nanomaterials with novel physicochemical properties or new functions are created and used in different research fields and industrial sectors, the scientific and public concerns about their toxic effects on human health and the environment are also growing quickly. In the past decade, the study of the toxicological properties of nanomaterials/nanoparticles has formed a new research field: nanotoxicology. However, most of the data published relate to toxicological phenomena and there is less understanding of the underlying mechanism for nanomaterial-induced toxicity. Nanomaterial-induced reactive oxygen species (ROS) play a key role in cellular and tissue toxicity. Herein, we classify the pathways for intracellular ROS production by nanomaterials into 1)the direct generation of ROS through nanomaterial-catalyzed free-radical reactions in cells, and 2)the indirect generation of ROS through disturbing the inherent biochemical equilibria in cells. We also discuss the chemical mechanisms associated with above pathways of intracellular ROS generation, from the viewpoint of the high reactivity of atoms on the nanosurface. We hope to aid in the understanding of the chemical origin of nanotoxicity to provide new insights for chemical and material scientists for the rational design and creation of safer and greener nanomaterials.
关键词nanoparticles oxygen reactive intermediates reaction mechanisms toxicity
学科领域Chemistry
DOI10.1002/asia.201300542
收录类别SCI
WOS记录号WOS:000324748600009
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224200
专题多学科研究中心
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GB/T 7714
Yan L,Gu ZJ,赵宇亮;Yan, L,et al. Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species[J]. CHEMISTRY-AN ASIAN JOURNAL,2013,8(SI10):2342-2353.
APA 晏亮,谷战军,赵宇亮;Yan, L,Gu, ZJ,&Zhao, YL.(2013).Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species.CHEMISTRY-AN ASIAN JOURNAL,8(SI10),2342-2353.
MLA 晏亮,et al."Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species".CHEMISTRY-AN ASIAN JOURNAL 8.SI10(2013):2342-2353.
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