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Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment
Xu, LG; Liu, Y; Chen, ZY; Li, W; Liu, Y; Wang, LM; Liu, Y; Wu, XC; Ji, YL; Zhao, YL; Ma, LY; Shao, YM; Chen, CY; 李炜(多); Wang LM(王黎明); Zhao YL(赵宇亮)
2012
发表期刊NANO LETTERS
卷号12期号:4页码:2003-2012
摘要With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or efficacy in humans. Adjuvants for HIV/AIDS vaccines are under intense research but a rational design approach is still lacking. Nanomaterials represent an obvious opportunity in this field due to their unique physicochemical properties. Gold nanostructures are being actively studied as a promising and versatile platform for biomedical application. Herein, we report novel surface-engineered gold nanorods (NRs) used as promising DNA vaccine adjuvant for HIV treatment. We have exploited the effects of surface chemistry on the adjuvant activity of the gold nanorod by placing three kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB), poly(diallydimethylammonium chloride) (PDDAC), and polyethyleneimine (PEI) on the surface of the nanorod. These PDDAC- or PEI-modified Au NRs can significantly promote cellular and humoral immunity as well as T cell proliferation through activating antigen-presenting cells if compared to naked HIV-1 Env plasmid DNA treatment in vivo. These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems.
关键词Gold nanorod surface chemistry adjuvant DNA vaccine HIV-1
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1021/nl300027p
收录类别SCI
WOS记录号WOS:000302524600044
引用统计
被引频次:139[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224183
专题多学科研究中心
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GB/T 7714
Xu, LG,Liu, Y,Chen, ZY,et al. Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment[J]. NANO LETTERS,2012,12(4):2003-2012.
APA Xu, LG.,Liu, Y.,Chen, ZY.,Li, W.,Liu, Y.,...&赵宇亮.(2012).Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment.NANO LETTERS,12(4),2003-2012.
MLA Xu, LG,et al."Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment".NANO LETTERS 12.4(2012):2003-2012.
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