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Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation
Gan T(甘田); Ren WL(任文璐); Yan L(晏亮); Tian, G; Ren, WL; Yan, L; Jian, S; Gu, ZJ; Zhou, LJ; Jin, S; Yin, WY; Li, SJ; Zhao, YL; Gu ZJ(谷战军); Zhou LJ(周良军); Jin S(金山); Yin WY(尹文艳); Zhao YL(赵宇亮)
2013
发表期刊SMALL
卷号9期号:11页码:1929-1938
摘要Upconverting nanoparticles (UCNPs) have attracted considerable attention as potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this work, a new and efficient NIR photosensitizing nanoplatform for PDT based on red-emitting UCNPs is designed. The red emission band matches well with the efficient absorption bands of the widely used commercially available photosensitizers (Ps), benefiting the fluorescence resonance energy transfer (FRET) from UCNPs to the attached photosensitizers and thus efficiently activating them to generate cytotoxic singlet oxygen. Three commonly used photosensitizers, including chlorine e6 (Ce6), zinc phthalocyanine (ZnPc) and methylene blue (MB), are loaded onto the alpha-cyclodextrin-modified UCNPs to form Ps@UCNPs complexes that efficiently produce singlet oxygen to kill cancer cells under 980 nm near-infrared excitation. Moreover, two different kinds of drugs are co-loaded onto these nanoparticles: chemotherapy drug doxorubicin and PDT agent Ce6. The combinational therapy based on doxorubicin (DOX)-induced chemotherapy and Ce6-triggered PDT exhibits higher therapeutic efficacy relative to the individual means for cancer therapy in vitro.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201201437
收录类别SCI
WOS记录号WOS:000319833700009
引用统计
被引频次:100[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224175
专题多学科研究中心
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GB/T 7714
Gan T,Ren WL,Yan L,et al. Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation[J]. SMALL,2013,9(11):1929-1938.
APA 甘田.,任文璐.,晏亮.,Tian, G.,Ren, WL.,...&赵宇亮.(2013).Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation.SMALL,9(11),1929-1938.
MLA 甘田,et al."Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation".SMALL 9.11(2013):1929-1938.
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