Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway
Meng, L; Chen, R; Jiang, AH; Wang, LM; Wang, P; Li, CZ; Bai, R; Zhao, YL; Autrup, H; Chen, CY; Wang LM(王黎明); Zhao YL(赵宇亮)
刊名SMALL
2013
卷号9期号:9-10 SI页码:1786-1798
关键词carbon nanotubes neuronal differentiation PC12 growth factors signaling pathways
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201201388
英文摘要Numerous unique properties of carbon nanotubes make them attractive for applications in neurobiology such as drug delivery, tissue regeneration, and as scaffolds for neuronal growth. In this study, the critical roles of the length of multiwall carbon nanotubes (MWCNTs) on a neuronal-like model cell line PC12 cells are investiaged. Incubation of PC12 cells with carboxylated MWCNTs did not significantly affect cellular morphology and viability at lower concentrations. Short MWCNTs show higher cellular uptake and more obvious removal compared to longer ones, which can result in higher ability to promote PC12 cell differentiation. Pre-incubation of short MWCNTs can up-regulate the expression of neurotrophin signaling pathway-associated TrkA/p75 receptors and Pincher/Gap43/TH proteins, which might be the underlying mechanism for the improved differentiation in PC12 cells. The current results provide insight for future applications of MWCNTs in neuron drug delivery and neurodegenerative disease treatment.
收录类别SCI
WOS记录号WOS:000319076000033
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224170
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Meng, L,Chen, R,Jiang, AH,et al. Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway[J]. SMALL,2013,9(9-10 SI):1786-1798.
APA Meng, L.,Chen, R.,Jiang, AH.,Wang, LM.,Wang, P.,...&赵宇亮.(2013).Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway.SMALL,9(9-10 SI),1786-1798.
MLA Meng, L,et al."Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway".SMALL 9.9-10 SI(2013):1786-1798.
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