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Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum
Chen, XX; Cheng, B; Yang, YX; Cao, AN; Liu, JH; Du, LJ; Liu, YF; Zhao, YL; Wang, HF; Zhao YL(赵宇亮)
2013
发表期刊SMALL
卷号9期号:9-10 SI页码:1765-1774
摘要Nanotechnology shows great potential for producing food with higher quality and better taste through including new additives, improving nutrient delivery, and using better packaging. However, lack of investigations on safety issues of nanofood has resulted in public fears. How to characterize engineered nanomaterials in food and assess the toxicity and health impact of nanofood remains a big challenge. Herein, a facile and highly reliable separation method of TiO2 particles from food products (focusing on sugar-coated chewing gum) is reported, and the first comprehensive characterization study on food nanoparticles by multiple qualitative and quantitative methods is provided. The detailed information on nanoparticles in gum includes chemical composition, morphology, size distribution, crystalline phase, particle and mass concentration, surface charge, and aggregation state. Surprisingly, the results show that the number of food products containing nano-TiO2 (<200 nm) is much larger than known, and consumers have already often been exposed to engineered nanoparticles in daily life. Over 93% of TiO2 in gum is nano-TiO2, and it is unexpectedly easy to come out and be swallowed by a person who chews gum. Preliminary cytotoxicity assays show that the gum nano-TiO2 particles are relatively safe for gastrointestinal cells within 24 h even at a concentration of 200 g mL1. This comprehensive study demonstrates accurate physicochemical property, exposure, and cytotoxicity information on engineered nanoparticles in food, which is a prerequisite for the successful safety assessment of nanofood products.
关键词characterization cytotoxicity food additives nanoparticles titanium dioxide
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201201506
收录类别SCI
WOS记录号WOS:000319076000031
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224168
专题多学科研究中心
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GB/T 7714
Chen, XX,Cheng, B,Yang, YX,et al. Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum[J]. SMALL,2013,9(9-10 SI):1765-1774.
APA Chen, XX.,Cheng, B.,Yang, YX.,Cao, AN.,Liu, JH.,...&赵宇亮.(2013).Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum.SMALL,9(9-10 SI),1765-1774.
MLA Chen, XX,et al."Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum".SMALL 9.9-10 SI(2013):1765-1774.
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